Elucidation of the pharmacokinetic/pharmacodynamic determinant of colistin activity against Pseudomonas aeruginosa in murine thigh and lung infection models

Rajesh Dudhani; John D Turnidge; Kingsley Coulthard; Robert Milne; Craig Robert Rayner; Jian Li; Roger Leigh Nation

doi:10.1128/AAC.01114-09

Elucidation of the pharmacokinetic/pharmacodynamic determinant of colistin activity against Pseudomonas aeruginosa in murine thigh and lung infection models

Rajesh Dudhani, John D Turnidge, Kingsley Coulthard, Robert Milne, Craig Robert Rayner, Jian Li, Roger Leigh Nation

Centre for Medicine Use and Safety

Research output: Contribution to journal › Article › Research › peer-review

137 Citations (Scopus)

Original language	English
Pages (from-to)	1117 - 1124
Number of pages	8
Journal	Antimicrobial Agents and Chemotherapy
Volume	54
Issue number	3
DOIs	https://doi.org/10.1128/AAC.01114-09
Publication status	Published - 2010

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10.1128/AAC.01114-09

2 Finished

Optimizing dosing of colistin for infections resistant to all other antibiotics.
Nation, R. & Li, J.
National Institutes of Health (United States)
15/09/08 → 31/08/12
Project: Research
Targeting MD hetero-resistant Gram-negatives: PK/PD for rational combinations.
Nation, R., Li, J., Forrest, A., Paterson, D. & Tsuji, B. T.
National Institutes of Health (United States)
15/07/08 → 30/06/12
Project: Research

Cite this

Dudhani, Rajesh ; Turnidge, John D ; Coulthard, Kingsley ; Milne, Robert ; Rayner, Craig Robert ; Li, Jian ; Nation, Roger Leigh. / Elucidation of the pharmacokinetic/pharmacodynamic determinant of colistin activity against Pseudomonas aeruginosa in murine thigh and lung infection models. In: Antimicrobial Agents and Chemotherapy. 2010 ; Vol. 54, No. 3. pp. 1117 - 1124.

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author = "Rajesh Dudhani and Turnidge, {John D} and Kingsley Coulthard and Robert Milne and Rayner, {Craig Robert} and Jian Li and Nation, {Roger Leigh}",

year = "2010",

doi = "10.1128/AAC.01114-09",

language = "English",

volume = "54",

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journal = "Antimicrobial Agents and Chemotherapy",

issn = "1098-6596",

publisher = "American Society for Microbiology",

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Elucidation of the pharmacokinetic/pharmacodynamic determinant of colistin activity against Pseudomonas aeruginosa in murine thigh and lung infection models. / Dudhani, Rajesh; Turnidge, John D; Coulthard, Kingsley; Milne, Robert; Rayner, Craig Robert; Li, Jian ; Nation, Roger Leigh.

In: Antimicrobial Agents and Chemotherapy, Vol. 54, No. 3, 2010, p. 1117 - 1124.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Elucidation of the pharmacokinetic/pharmacodynamic determinant of colistin activity against Pseudomonas aeruginosa in murine thigh and lung infection models

AU - Dudhani, Rajesh

AU - Turnidge, John D

AU - Coulthard, Kingsley

AU - Milne, Robert

AU - Rayner, Craig Robert

AU - Li, Jian

AU - Nation, Roger Leigh

PY - 2010

Y1 - 2010

U2 - 10.1128/AAC.01114-09

DO - 10.1128/AAC.01114-09

M3 - Article

C2 - 20028824

VL - 54

SP - 1117

EP - 1124

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 1098-6596

IS - 3

ER -

Elucidation of the pharmacokinetic/pharmacodynamic determinant of colistin activity against Pseudomonas aeruginosa in murine thigh and lung infection models

Access to Document

Projects

Optimizing dosing of colistin for infections resistant to all other antibiotics.

Targeting MD hetero-resistant Gram-negatives: PK/PD for rational combinations.

Cite this