Elucidation of the pharmacokinetic/pharmacodynamic determinant of colistin activity against Pseudomonas aeruginosa in murine thigh and lung infection models

Rajesh Dudhani; John D Turnidge; Kingsley Coulthard; Robert Milne; Craig Robert Rayner; Jian Li; Roger Leigh Nation

doi:10.1128/AAC.01114-09

Elucidation of the pharmacokinetic/pharmacodynamic determinant of colistin activity against Pseudomonas aeruginosa in murine thigh and lung infection models

Rajesh Dudhani, John D Turnidge, Kingsley Coulthard, Robert Milne, Craig Robert Rayner, Jian Li, Roger Leigh Nation

Centre for Medicine Use and Safety

Research output: Contribution to journal › Article › Research › peer-review

168 Citations (Scopus)

Original language	English
Pages (from-to)	1117 - 1124
Number of pages	8
Journal	Antimicrobial Agents and Chemotherapy
Volume	54
Issue number	3
DOIs	https://doi.org/10.1128/AAC.01114-09
Publication status	Published - 2010

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10.1128/AAC.01114-09

Optimizing dosing of colistin for infections resistant to all other antibiotics.
Nation, R. (Primary Chief Investigator (PCI)) & Li, J. (Chief Investigator (CI))
NIH - National Institutes of Health (United States of America)
15/09/08 → 31/08/12
Project: Research
Targeting MD hetero-resistant Gram-negatives: PK/PD for rational combinations.
Nation, R. (Primary Chief Investigator (PCI)), Li, J. (Chief Investigator (CI)), Forrest, A. (Partner Investigator (PI)), Paterson, D. L. (Partner Investigator (PI)) & Tsuji, B. T. (Partner Investigator (PI))
NIH - National Institutes of Health (United States of America)
15/07/08 → 30/06/12
Project: Research

Cite this

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title = "Elucidation of the pharmacokinetic/pharmacodynamic determinant of colistin activity against Pseudomonas aeruginosa in murine thigh and lung infection models",

author = "Rajesh Dudhani and Turnidge, {John D} and Kingsley Coulthard and Robert Milne and Rayner, {Craig Robert} and Jian Li and Nation, {Roger Leigh}",

year = "2010",

doi = "10.1128/AAC.01114-09",

language = "English",

volume = "54",

pages = "1117 -- 1124",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "3",

}

Elucidation of the pharmacokinetic/pharmacodynamic determinant of colistin activity against Pseudomonas aeruginosa in murine thigh and lung infection models. / Dudhani, Rajesh; Turnidge, John D; Coulthard, Kingsley et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 54, No. 3, 2010, p. 1117 - 1124.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Elucidation of the pharmacokinetic/pharmacodynamic determinant of colistin activity against Pseudomonas aeruginosa in murine thigh and lung infection models

AU - Dudhani, Rajesh

AU - Turnidge, John D

AU - Coulthard, Kingsley

AU - Milne, Robert

AU - Rayner, Craig Robert

AU - Li, Jian

AU - Nation, Roger Leigh

PY - 2010

Y1 - 2010

U2 - 10.1128/AAC.01114-09

DO - 10.1128/AAC.01114-09

M3 - Article

C2 - 20028824

SN - 0066-4804

VL - 54

SP - 1117

EP - 1124

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 3

ER -

Elucidation of the pharmacokinetic/pharmacodynamic determinant of colistin activity against Pseudomonas aeruginosa in murine thigh and lung infection models

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Projects

Optimizing dosing of colistin for infections resistant to all other antibiotics.

Targeting MD hetero-resistant Gram-negatives: PK/PD for rational combinations.

Cite this