Elucidating the pharmacokinetics/pharmacodynamics of aerosolized colistin against multidrug-resistant acinetobacter baumannii and klebsiella pneumoniae in a mouse lung infection model

Yu-Wei Lin; Qi Tony Zhou; Mei-Ling Han; Ke Chen; Nikolas J. Onufrak; Jiping Wang; John D. Turnidge; Benjamin P. Howden; Alan Forrest; Hak Kim Chan; Jian Li

doi:10.1128/AAC.01790-17

Elucidating the pharmacokinetics/pharmacodynamics of aerosolized colistin against multidrug-resistant acinetobacter baumannii and klebsiella pneumoniae in a mouse lung infection model

Yu-Wei Lin, Qi Tony Zhou, Mei-Ling Han, Ke Chen, Nikolas J. Onufrak, Jiping Wang, John D. Turnidge, Benjamin P. Howden, Alan Forrest, Hak Kim Chan, Jian Li

Research output: Contribution to journal › Article › Research › peer-review

14 Citations (Scopus)

Abstract

The pharmacokinetics/pharmacodynamics (PK/PD) of aerosolized colistin was investigated against Acinetobacter baumannii and Klebsiella pneumoniae over 24 h in a neutropenic mouse lung infection model. Dose fractionation studies were performed over 2.64 to 23.8 mg/kg/day, and the data were fitted to a sigmoid inhibitory model. The area under the concentration-time curve over 24 h in the steady state divided by the MIC (AUC/MIC) in the epithelial lining fluid was the most predictive PK/PD index for aerosolized colistin against both pathogens. Our study provides important pharmacological information for optimizing aerosolized colistin.

Original language	English
Article number	e01790
Number of pages	9
Journal	Antimicrobial Agents and Chemotherapy
Volume	62
Issue number	2
DOIs	https://doi.org/10.1128/AAC.01790-17
Publication status	Published - 1 Feb 2018

Keywords

Acinetobacter baumannii
Gram-negative bacteria
Klebsiella pneumoniae
Polymyxin
Pulmonary administration
Respiratory tract infections

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.01790-17

235403803-oaFinal published version, 944 KB

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Lin, Y.-W., Zhou, Q. T., Han, M.-L., Chen, K., Onufrak, N. J., Wang, J., Turnidge, J. D., Howden, B. P., Forrest, A., Chan, H. K., & Li, J. (2018). Elucidating the pharmacokinetics/pharmacodynamics of aerosolized colistin against multidrug-resistant acinetobacter baumannii and klebsiella pneumoniae in a mouse lung infection model. Antimicrobial Agents and Chemotherapy, 62(2), Article e01790. https://doi.org/10.1128/AAC.01790-17

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abstract = "The pharmacokinetics/pharmacodynamics (PK/PD) of aerosolized colistin was investigated against Acinetobacter baumannii and Klebsiella pneumoniae over 24 h in a neutropenic mouse lung infection model. Dose fractionation studies were performed over 2.64 to 23.8 mg/kg/day, and the data were fitted to a sigmoid inhibitory model. The area under the concentration-time curve over 24 h in the steady state divided by the MIC (AUC/MIC) in the epithelial lining fluid was the most predictive PK/PD index for aerosolized colistin against both pathogens. Our study provides important pharmacological information for optimizing aerosolized colistin.",

keywords = "Acinetobacter baumannii, Gram-negative bacteria, Klebsiella pneumoniae, Polymyxin, Pulmonary administration, Respiratory tract infections",

author = "Yu-Wei Lin and Zhou, {Qi Tony} and Mei-Ling Han and Ke Chen and Onufrak, {Nikolas J.} and Jiping Wang and Turnidge, {John D.} and Howden, {Benjamin P.} and Alan Forrest and Chan, {Hak Kim} and Jian Li",

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Lin, Y-W, Zhou, QT, Han, M-L, Chen, K, Onufrak, NJ, Wang, J, Turnidge, JD, Howden, BP, Forrest, A, Chan, HK & Li, J 2018, 'Elucidating the pharmacokinetics/pharmacodynamics of aerosolized colistin against multidrug-resistant acinetobacter baumannii and klebsiella pneumoniae in a mouse lung infection model', Antimicrobial Agents and Chemotherapy, vol. 62, no. 2, e01790. https://doi.org/10.1128/AAC.01790-17

Elucidating the pharmacokinetics/pharmacodynamics of aerosolized colistin against multidrug-resistant acinetobacter baumannii and klebsiella pneumoniae in a mouse lung infection model. / Lin, Yu-Wei; Zhou, Qi Tony; Han, Mei-Ling et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 62, No. 2, e01790, 01.02.2018.

Research output: Contribution to journal › Article › Research › peer-review

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AU - Lin, Yu-Wei

AU - Zhou, Qi Tony

AU - Han, Mei-Ling

AU - Chen, Ke

AU - Onufrak, Nikolas J.

AU - Wang, Jiping

AU - Turnidge, John D.

AU - Howden, Benjamin P.

AU - Forrest, Alan

AU - Chan, Hak Kim

AU - Li, Jian

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KW - Gram-negative bacteria

KW - Klebsiella pneumoniae

KW - Polymyxin

KW - Pulmonary administration

KW - Respiratory tract infections

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Elucidating the pharmacokinetics/pharmacodynamics of aerosolized colistin against multidrug-resistant acinetobacter baumannii and klebsiella pneumoniae in a mouse lung infection model

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Novel inhalation formulation of colistin and combination therapy against Gram-negative 'superbugs'.

Cite this

Elucidating the pharmacokinetics/pharmacodynamics of aerosolized colistin against multidrug-resistant acinetobacter baumannii and klebsiella pneumoniae in a mouse lung infection model

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Projects

Novel inhalation formulation of colistin and combination therapy against Gram-negative 'superbugs'.

Cite this