The proteins ELN and FBN2 are important in extracellular matrix function. The ELN rs2071307 and FBN2 rs331079 gene variants have been associated with soft tissue pathologies. We aimed to determine whether these variants were pre-disposing factors for both Achilles tendinopathy (AT) and anterior cruciate ligament (ACL) rup-tures. For the AT study, 135 cases (TEN group) and 239 asymptomatic controls were recruited. For the ACL rupture study our cohort consisted of 141 cases (ACL group) and 219 controls.
El Khoury, L. Y., Posthumus, M., Collins, M., van der Merwe, W., Handley, C. J., Cook, J. L., & Raleigh, S. M. (2015). ELN and FBN2 gene variants as risk factors for two sports-related musculoskeletal injuries. International Journal of Sports Medicine, 36(4), 333 - 337. https://doi.org/10.1055/s-0034-1390492