TY - JOUR
T1 - Elevated secretory IgA antibodies to Epstein-Barr Virus (EBV) and presence of EBV DNA and EBV receptors in patients with cervical carcinoma
AU - Thoe, S. Y.Se
AU - Wong, K. K.
AU - Pathmanathan, R.
AU - Sam, C. K.
AU - Cheng, H. M.
AU - Prasad, U.
PY - 1993/8
Y1 - 1993/8
N2 - Epstein-Barr virus (EBV) receptors (EBV/C3d receptors) were detected, using the monoclonal antibody HB5, on 23 ectocervical and 5 endocervical biopsies of the uterine cervix. Elevated IgA liters against the viral capsid antigen and early antigen of EBV were also found in the cervical secretions from cervical carcinoma patients (83%), compared with samples from patients with cervical intraepithelial neoplasia (75%), herpes simplex virus-infected patients (0%), and gynecologic patients with nonmalignant conditions (0%). EBV DNA was present in 63% of cervical carcinoma biopsies detected by in situ hybridization. These observations suggest a positive association between EBV and carcinoma of the cervix.
AB - Epstein-Barr virus (EBV) receptors (EBV/C3d receptors) were detected, using the monoclonal antibody HB5, on 23 ectocervical and 5 endocervical biopsies of the uterine cervix. Elevated IgA liters against the viral capsid antigen and early antigen of EBV were also found in the cervical secretions from cervical carcinoma patients (83%), compared with samples from patients with cervical intraepithelial neoplasia (75%), herpes simplex virus-infected patients (0%), and gynecologic patients with nonmalignant conditions (0%). EBV DNA was present in 63% of cervical carcinoma biopsies detected by in situ hybridization. These observations suggest a positive association between EBV and carcinoma of the cervix.
UR - http://www.scopus.com/inward/record.url?scp=0027181526&partnerID=8YFLogxK
U2 - 10.1006/gyno.1993.1187
DO - 10.1006/gyno.1993.1187
M3 - Article
C2 - 8397152
AN - SCOPUS:0027181526
SN - 0090-8258
VL - 50
SP - 168
EP - 172
JO - Gynecologic Oncology
JF - Gynecologic Oncology
IS - 2
ER -