Elevated plasma prostaglandins and acetylated histone in monocytes in Type 1 diabetes patients: Short Report

Suzi Chen, A J Jenkins, H Majewski

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AIMS/HYPOTHESIS: Inflammation is implicated in diabetes and cyclooxygenase (COX) is involved in vascular inflammatory processes, participating in both atherosclerosis and thrombosis. The aims were to determine whether levels of monocyte COX and plasma COX metabolites are increased in Type 1 diabetic patients and to determine whether these could be linked to histone hyperacetylation. MATERIALS AND METHODS: Monocytes from 19 Type 1 diabetic and 39 non-diabetic control subjects were probed for COX and acetylated histone H4 proteins by immunoblotting.
Original languageEnglish
Pages (from-to)182 - 186
Number of pages5
JournalDiabetic Medicine
Issue number2
Publication statusPublished - 2009

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