Elevated blood pressure during sleep and wake in children with sleep-disordered breathing

Rosemary Sylvia Claire Horne, Joel Shao-Chung Yang, Lisa Walter, Heidi Richardson, Denise O'Driscoll, Alison Foster, Shi Wong, Michelle Ng, Farhat Bashir, Ruth Patterson, Gillian Nixon, Damien Jolley, Adrian Walker, Vicki Anderson, John Trinder, Margot Davey

Research output: Contribution to journalArticleResearchpeer-review

98 Citations (Scopus)

Abstract

OBJECTIVE: Sleep-disordered breathing (SDB) in adults has been associated with elevated blood pressure (BP); however, the effects of severity of SDB on BP in children are uncertain. We addressed this issue by measuring BP noninvasively and continuously during sleep in children with a range of severities of SDB and in a group of nonsnoring control children. METHODS: A total of 105 children referred for assessment of SDB and 36 nonsnoring controls were studied. Routine polysomnography (PSG) was performed with continuous BP monitoring. Children were assigned to groups according to obstructive apnea/hypopnea index (OAHI). BP data were categorized as quiet awake (recorded before sleep onset), non-rapid eye movement sleep 1 and 2 combined, slow-wave sleep, and rapid eye movement sleep. RESULTS: BP during awake before sleep onset and during overnight sleep was elevated by 10 to 15 mm Hg in the 3 SDB groups compared with the control group; this finding was independent of SDB severity. BP during stable sleep (with respiratory events and movements excluded) was also elevated in the children with OSA compared with the control group. BP was elevated in rapid eye movement sleep compared with the non-rapid eye movement sleep, and heart rate was higher during wake state than in all sleep states. CONCLUSIONS: We recorded BP continuously overnight and found that SDB, regardless of the severity, was associated with increased BP during sleep and wake compared with nonsnoring control children. These findings highlight the importance of considering the cardiovascular effects of SDB of any severity in children, and the need to review current clinical management that focuses primarily on more severe SDB.
Original languageEnglish
Pages (from-to)e85 - e92
Number of pages8
JournalPediatrics
Volume128
Issue number1
DOIs
Publication statusPublished - 2011

Cite this

Horne, Rosemary Sylvia Claire ; Yang, Joel Shao-Chung ; Walter, Lisa ; Richardson, Heidi ; O'Driscoll, Denise ; Foster, Alison ; Wong, Shi ; Ng, Michelle ; Bashir, Farhat ; Patterson, Ruth ; Nixon, Gillian ; Jolley, Damien ; Walker, Adrian ; Anderson, Vicki ; Trinder, John ; Davey, Margot. / Elevated blood pressure during sleep and wake in children with sleep-disordered breathing. In: Pediatrics. 2011 ; Vol. 128, No. 1. pp. e85 - e92.
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title = "Elevated blood pressure during sleep and wake in children with sleep-disordered breathing",
abstract = "OBJECTIVE: Sleep-disordered breathing (SDB) in adults has been associated with elevated blood pressure (BP); however, the effects of severity of SDB on BP in children are uncertain. We addressed this issue by measuring BP noninvasively and continuously during sleep in children with a range of severities of SDB and in a group of nonsnoring control children. METHODS: A total of 105 children referred for assessment of SDB and 36 nonsnoring controls were studied. Routine polysomnography (PSG) was performed with continuous BP monitoring. Children were assigned to groups according to obstructive apnea/hypopnea index (OAHI). BP data were categorized as quiet awake (recorded before sleep onset), non-rapid eye movement sleep 1 and 2 combined, slow-wave sleep, and rapid eye movement sleep. RESULTS: BP during awake before sleep onset and during overnight sleep was elevated by 10 to 15 mm Hg in the 3 SDB groups compared with the control group; this finding was independent of SDB severity. BP during stable sleep (with respiratory events and movements excluded) was also elevated in the children with OSA compared with the control group. BP was elevated in rapid eye movement sleep compared with the non-rapid eye movement sleep, and heart rate was higher during wake state than in all sleep states. CONCLUSIONS: We recorded BP continuously overnight and found that SDB, regardless of the severity, was associated with increased BP during sleep and wake compared with nonsnoring control children. These findings highlight the importance of considering the cardiovascular effects of SDB of any severity in children, and the need to review current clinical management that focuses primarily on more severe SDB.",
author = "Horne, {Rosemary Sylvia Claire} and Yang, {Joel Shao-Chung} and Lisa Walter and Heidi Richardson and Denise O'Driscoll and Alison Foster and Shi Wong and Michelle Ng and Farhat Bashir and Ruth Patterson and Gillian Nixon and Damien Jolley and Adrian Walker and Vicki Anderson and John Trinder and Margot Davey",
year = "2011",
doi = "10.1542/peds.2010-3431",
language = "English",
volume = "128",
pages = "e85 -- e92",
journal = "Pediatrics",
issn = "0031-4005",
publisher = "American Academy of Pediatrics (AAP)",
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Horne, RSC, Yang, JS-C, Walter, L, Richardson, H, O'Driscoll, D, Foster, A, Wong, S, Ng, M, Bashir, F, Patterson, R, Nixon, G, Jolley, D, Walker, A, Anderson, V, Trinder, J & Davey, M 2011, 'Elevated blood pressure during sleep and wake in children with sleep-disordered breathing', Pediatrics, vol. 128, no. 1, pp. e85 - e92. https://doi.org/10.1542/peds.2010-3431

Elevated blood pressure during sleep and wake in children with sleep-disordered breathing. / Horne, Rosemary Sylvia Claire; Yang, Joel Shao-Chung; Walter, Lisa; Richardson, Heidi; O'Driscoll, Denise; Foster, Alison; Wong, Shi; Ng, Michelle; Bashir, Farhat; Patterson, Ruth; Nixon, Gillian; Jolley, Damien; Walker, Adrian; Anderson, Vicki; Trinder, John; Davey, Margot.

In: Pediatrics, Vol. 128, No. 1, 2011, p. e85 - e92.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Elevated blood pressure during sleep and wake in children with sleep-disordered breathing

AU - Horne, Rosemary Sylvia Claire

AU - Yang, Joel Shao-Chung

AU - Walter, Lisa

AU - Richardson, Heidi

AU - O'Driscoll, Denise

AU - Foster, Alison

AU - Wong, Shi

AU - Ng, Michelle

AU - Bashir, Farhat

AU - Patterson, Ruth

AU - Nixon, Gillian

AU - Jolley, Damien

AU - Walker, Adrian

AU - Anderson, Vicki

AU - Trinder, John

AU - Davey, Margot

PY - 2011

Y1 - 2011

N2 - OBJECTIVE: Sleep-disordered breathing (SDB) in adults has been associated with elevated blood pressure (BP); however, the effects of severity of SDB on BP in children are uncertain. We addressed this issue by measuring BP noninvasively and continuously during sleep in children with a range of severities of SDB and in a group of nonsnoring control children. METHODS: A total of 105 children referred for assessment of SDB and 36 nonsnoring controls were studied. Routine polysomnography (PSG) was performed with continuous BP monitoring. Children were assigned to groups according to obstructive apnea/hypopnea index (OAHI). BP data were categorized as quiet awake (recorded before sleep onset), non-rapid eye movement sleep 1 and 2 combined, slow-wave sleep, and rapid eye movement sleep. RESULTS: BP during awake before sleep onset and during overnight sleep was elevated by 10 to 15 mm Hg in the 3 SDB groups compared with the control group; this finding was independent of SDB severity. BP during stable sleep (with respiratory events and movements excluded) was also elevated in the children with OSA compared with the control group. BP was elevated in rapid eye movement sleep compared with the non-rapid eye movement sleep, and heart rate was higher during wake state than in all sleep states. CONCLUSIONS: We recorded BP continuously overnight and found that SDB, regardless of the severity, was associated with increased BP during sleep and wake compared with nonsnoring control children. These findings highlight the importance of considering the cardiovascular effects of SDB of any severity in children, and the need to review current clinical management that focuses primarily on more severe SDB.

AB - OBJECTIVE: Sleep-disordered breathing (SDB) in adults has been associated with elevated blood pressure (BP); however, the effects of severity of SDB on BP in children are uncertain. We addressed this issue by measuring BP noninvasively and continuously during sleep in children with a range of severities of SDB and in a group of nonsnoring control children. METHODS: A total of 105 children referred for assessment of SDB and 36 nonsnoring controls were studied. Routine polysomnography (PSG) was performed with continuous BP monitoring. Children were assigned to groups according to obstructive apnea/hypopnea index (OAHI). BP data were categorized as quiet awake (recorded before sleep onset), non-rapid eye movement sleep 1 and 2 combined, slow-wave sleep, and rapid eye movement sleep. RESULTS: BP during awake before sleep onset and during overnight sleep was elevated by 10 to 15 mm Hg in the 3 SDB groups compared with the control group; this finding was independent of SDB severity. BP during stable sleep (with respiratory events and movements excluded) was also elevated in the children with OSA compared with the control group. BP was elevated in rapid eye movement sleep compared with the non-rapid eye movement sleep, and heart rate was higher during wake state than in all sleep states. CONCLUSIONS: We recorded BP continuously overnight and found that SDB, regardless of the severity, was associated with increased BP during sleep and wake compared with nonsnoring control children. These findings highlight the importance of considering the cardiovascular effects of SDB of any severity in children, and the need to review current clinical management that focuses primarily on more severe SDB.

UR - http://www.ncbi.nlm.nih.gov/pubmed/21708802

U2 - 10.1542/peds.2010-3431

DO - 10.1542/peds.2010-3431

M3 - Article

VL - 128

SP - e85 - e92

JO - Pediatrics

JF - Pediatrics

SN - 0031-4005

IS - 1

ER -