Elements of RAFT Navigation: RAFT 20 Years Later: RAFT-Synthesis of Uniform, Sequence-Defined (Co)polymers

Joris J. Haven, Matthew Hendrikx, Tanja Junkers, Pieter J. Leenaers, Theodora Tsompanoglou, Cyrille Boyer, Jiangtao Xu, Almar Postma, Graeme Moad

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

8 Citations (Scopus)


This paper focuses on one of the next directions in the evolution of reversible addition-fragmentation (RAFT) polymerization, namely, progress towards the synthesis of discrete or uniform, sequence-defined (co)polymers. Following a brief review of RAFT-single unit monomer insertion (RAFT-SUMI), we describe recent developments in the field. We point to difficulties in achieving consecutive RAFT-SUMI and report two strategies for overcoming the issue of initiator-derived by-products. We show that the selection of RAFT agent is critical in selective RAFT-SUMI of N,N-dimethylacrylamide (DMAm) into a trithiocarbonate in aqueous solution. Finally we recount on the use of photoRAFT- or PET-RAFT-SUMI in the high yield synthesis of discrete oligomers comprising two or more consecutive SUMI steps.

Original languageEnglish
Title of host publicationReversible Deactivation Radical Polymerization
Subtitle of host publicationMechanisms and Synthetic Methodologies
EditorsKrzysztof Matyjaszewski, Haifeng Gao, Brent S. Sumerlin, Nicolay V. Tsarevsky
Place of PublicationWashington DC
PublisherAmerican Chemical Society
Number of pages27
ISBN (Print)9780841233188
Publication statusPublished - 1 Jan 2018
EventAmerican-Chemical-Society Symposium on Controlled/Living Radical Polymerization 2017 - Washington, United States of America
Duration: 20 Aug 201724 Aug 2017
https://pubs-acs-org.ezproxy.lib.monash.edu.au/doi/pdf/10.1021/bk-2018-1284.pr001 (preface)
https://pubs-acs-org.ezproxy.lib.monash.edu.au/doi/pdf/10.1021/bk-2018-1284.fw001 (front matter)

Publication series

NameACS Symposium Series
ISSN (Print)0097-6156
ISSN (Electronic)1947-5918


ConferenceAmerican-Chemical-Society Symposium on Controlled/Living Radical Polymerization 2017
CountryUnited States of America
Internet address

Cite this

Haven, J. J., Hendrikx, M., Junkers, T., Leenaers, P. J., Tsompanoglou, T., Boyer, C., Xu, J., Postma, A., & Moad, G. (2018). Elements of RAFT Navigation: RAFT 20 Years Later: RAFT-Synthesis of Uniform, Sequence-Defined (Co)polymers. In K. Matyjaszewski, H. Gao, B. S. Sumerlin, & N. V. Tsarevsky (Eds.), Reversible Deactivation Radical Polymerization: Mechanisms and Synthetic Methodologies (pp. 77-103). (ACS Symposium Series; Vol. 1284). American Chemical Society. https://doi.org/10.1021/bk-2018-1284.ch004