Elements of RAFT Navigation

RAFT 20 Years Later: RAFT-Synthesis of Uniform, Sequence-Defined (Co)polymers

Joris J. Haven, Matthew Hendrikx, Tanja Junkers, Pieter J. Leenaers, Theodora Tsompanoglou, Cyrille Boyer, Jiangtao Xu, Almar Postma, Graeme Moad

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

3 Citations (Scopus)

Abstract

This paper focuses on one of the next directions in the evolution of reversible addition-fragmentation (RAFT) polymerization, namely, progress towards the synthesis of discrete or uniform, sequence-defined (co)polymers. Following a brief review of RAFT-single unit monomer insertion (RAFT-SUMI), we describe recent developments in the field. We point to difficulties in achieving consecutive RAFT-SUMI and report two strategies for overcoming the issue of initiator-derived by-products. We show that the selection of RAFT agent is critical in selective RAFT-SUMI of N,N-dimethylacrylamide (DMAm) into a trithiocarbonate in aqueous solution. Finally we recount on the use of photoRAFT- or PET-RAFT-SUMI in the high yield synthesis of discrete oligomers comprising two or more consecutive SUMI steps.

Original languageEnglish
Title of host publicationReversible Deactivation Radical Polymerization
Subtitle of host publicationMechanisms and Synthetic Methodologies
EditorsKrzysztof Matyjaszewski, Haifeng Gao, Brent S. Sumerlin, Nicolay V. Tsarevsky
Place of PublicationWashington DC
PublisherAmerican Chemical Society (ACS)
Chapter4
Pages77-103
Number of pages27
ISBN (Print)9780841233188
DOIs
Publication statusPublished - 1 Jan 2018
EventAmerican-Chemical-Society Symposium on Controlled/Living Radical Polymerization 2017 - Washington, United States of America
Duration: 20 Aug 201724 Aug 2017
https://pubs-acs-org.ezproxy.lib.monash.edu.au/doi/pdf/10.1021/bk-2018-1284.pr001 (preface)
https://pubs-acs-org.ezproxy.lib.monash.edu.au/doi/pdf/10.1021/bk-2018-1284.fw001 (front matter)

Publication series

NameACS Symposium Series
Volume1284
ISSN (Print)0097-6156
ISSN (Electronic)1947-5918

Conference

ConferenceAmerican-Chemical-Society Symposium on Controlled/Living Radical Polymerization 2017
CountryUnited States of America
CityWashington
Period20/08/1724/08/17
Internet address

Cite this

Haven, J. J., Hendrikx, M., Junkers, T., Leenaers, P. J., Tsompanoglou, T., Boyer, C., ... Moad, G. (2018). Elements of RAFT Navigation: RAFT 20 Years Later: RAFT-Synthesis of Uniform, Sequence-Defined (Co)polymers. In K. Matyjaszewski, H. Gao, B. S. Sumerlin, & N. V. Tsarevsky (Eds.), Reversible Deactivation Radical Polymerization: Mechanisms and Synthetic Methodologies (pp. 77-103). (ACS Symposium Series; Vol. 1284). Washington DC: American Chemical Society (ACS). https://doi.org/10.1021/bk-2018-1284.ch004
Haven, Joris J. ; Hendrikx, Matthew ; Junkers, Tanja ; Leenaers, Pieter J. ; Tsompanoglou, Theodora ; Boyer, Cyrille ; Xu, Jiangtao ; Postma, Almar ; Moad, Graeme. / Elements of RAFT Navigation : RAFT 20 Years Later: RAFT-Synthesis of Uniform, Sequence-Defined (Co)polymers. Reversible Deactivation Radical Polymerization: Mechanisms and Synthetic Methodologies. editor / Krzysztof Matyjaszewski ; Haifeng Gao ; Brent S. Sumerlin ; Nicolay V. Tsarevsky. Washington DC : American Chemical Society (ACS), 2018. pp. 77-103 (ACS Symposium Series).
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title = "Elements of RAFT Navigation: RAFT 20 Years Later: RAFT-Synthesis of Uniform, Sequence-Defined (Co)polymers",
abstract = "This paper focuses on one of the next directions in the evolution of reversible addition-fragmentation (RAFT) polymerization, namely, progress towards the synthesis of discrete or uniform, sequence-defined (co)polymers. Following a brief review of RAFT-single unit monomer insertion (RAFT-SUMI), we describe recent developments in the field. We point to difficulties in achieving consecutive RAFT-SUMI and report two strategies for overcoming the issue of initiator-derived by-products. We show that the selection of RAFT agent is critical in selective RAFT-SUMI of N,N-dimethylacrylamide (DMAm) into a trithiocarbonate in aqueous solution. Finally we recount on the use of photoRAFT- or PET-RAFT-SUMI in the high yield synthesis of discrete oligomers comprising two or more consecutive SUMI steps.",
author = "Haven, {Joris J.} and Matthew Hendrikx and Tanja Junkers and Leenaers, {Pieter J.} and Theodora Tsompanoglou and Cyrille Boyer and Jiangtao Xu and Almar Postma and Graeme Moad",
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Haven, JJ, Hendrikx, M, Junkers, T, Leenaers, PJ, Tsompanoglou, T, Boyer, C, Xu, J, Postma, A & Moad, G 2018, Elements of RAFT Navigation: RAFT 20 Years Later: RAFT-Synthesis of Uniform, Sequence-Defined (Co)polymers. in K Matyjaszewski, H Gao, BS Sumerlin & NV Tsarevsky (eds), Reversible Deactivation Radical Polymerization: Mechanisms and Synthetic Methodologies. ACS Symposium Series, vol. 1284, American Chemical Society (ACS), Washington DC, pp. 77-103, American-Chemical-Society Symposium on Controlled/Living Radical Polymerization 2017, Washington, United States of America, 20/08/17. https://doi.org/10.1021/bk-2018-1284.ch004

Elements of RAFT Navigation : RAFT 20 Years Later: RAFT-Synthesis of Uniform, Sequence-Defined (Co)polymers. / Haven, Joris J.; Hendrikx, Matthew; Junkers, Tanja; Leenaers, Pieter J.; Tsompanoglou, Theodora; Boyer, Cyrille; Xu, Jiangtao; Postma, Almar; Moad, Graeme.

Reversible Deactivation Radical Polymerization: Mechanisms and Synthetic Methodologies. ed. / Krzysztof Matyjaszewski; Haifeng Gao; Brent S. Sumerlin; Nicolay V. Tsarevsky. Washington DC : American Chemical Society (ACS), 2018. p. 77-103 (ACS Symposium Series; Vol. 1284).

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

TY - GEN

T1 - Elements of RAFT Navigation

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AU - Haven, Joris J.

AU - Hendrikx, Matthew

AU - Junkers, Tanja

AU - Leenaers, Pieter J.

AU - Tsompanoglou, Theodora

AU - Boyer, Cyrille

AU - Xu, Jiangtao

AU - Postma, Almar

AU - Moad, Graeme

PY - 2018/1/1

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N2 - This paper focuses on one of the next directions in the evolution of reversible addition-fragmentation (RAFT) polymerization, namely, progress towards the synthesis of discrete or uniform, sequence-defined (co)polymers. Following a brief review of RAFT-single unit monomer insertion (RAFT-SUMI), we describe recent developments in the field. We point to difficulties in achieving consecutive RAFT-SUMI and report two strategies for overcoming the issue of initiator-derived by-products. We show that the selection of RAFT agent is critical in selective RAFT-SUMI of N,N-dimethylacrylamide (DMAm) into a trithiocarbonate in aqueous solution. Finally we recount on the use of photoRAFT- or PET-RAFT-SUMI in the high yield synthesis of discrete oligomers comprising two or more consecutive SUMI steps.

AB - This paper focuses on one of the next directions in the evolution of reversible addition-fragmentation (RAFT) polymerization, namely, progress towards the synthesis of discrete or uniform, sequence-defined (co)polymers. Following a brief review of RAFT-single unit monomer insertion (RAFT-SUMI), we describe recent developments in the field. We point to difficulties in achieving consecutive RAFT-SUMI and report two strategies for overcoming the issue of initiator-derived by-products. We show that the selection of RAFT agent is critical in selective RAFT-SUMI of N,N-dimethylacrylamide (DMAm) into a trithiocarbonate in aqueous solution. Finally we recount on the use of photoRAFT- or PET-RAFT-SUMI in the high yield synthesis of discrete oligomers comprising two or more consecutive SUMI steps.

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M3 - Conference Paper

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BT - Reversible Deactivation Radical Polymerization

A2 - Matyjaszewski, Krzysztof

A2 - Gao, Haifeng

A2 - Sumerlin, Brent S.

A2 - Tsarevsky, Nicolay V.

PB - American Chemical Society (ACS)

CY - Washington DC

ER -

Haven JJ, Hendrikx M, Junkers T, Leenaers PJ, Tsompanoglou T, Boyer C et al. Elements of RAFT Navigation: RAFT 20 Years Later: RAFT-Synthesis of Uniform, Sequence-Defined (Co)polymers. In Matyjaszewski K, Gao H, Sumerlin BS, Tsarevsky NV, editors, Reversible Deactivation Radical Polymerization: Mechanisms and Synthetic Methodologies. Washington DC: American Chemical Society (ACS). 2018. p. 77-103. (ACS Symposium Series). https://doi.org/10.1021/bk-2018-1284.ch004