Abstract
Regeneration of the brain following injury is often slow or ineffective due to a dearth of cellular cues that support and guide neural regeneration. Scaffolds have been actively investigated for new therapies targeting neurodegenerative diseases and traumatic brain injury. Electrospinning offers many advantages for the fabrication of a diverse and tunable range of neural scaffolds. The architecture of electrospun scaffolds can be tailored to meet specific requirements such as the culture of different types of neural cells and the incorporation and delivery of bioactive molecules. Electrospun fibers have been highly successful in providing both biological and physical cues to repair the injured brain. This chapter provides an overview of the design principles of electrospun scaffolds for neural tissue engineering, with a focus on brain repair.
| Original language | English |
|---|---|
| Title of host publication | Electrospun Materials for Tissue Engineering and Biomedical Applications |
| Subtitle of host publication | Research, Design and Commercialization |
| Editors | Tamer Uyar, Erich Kny |
| Place of Publication | Duxford UK |
| Publisher | Woodhead Publishing Limited |
| Chapter | 13 |
| Pages | 299-320 |
| Number of pages | 22 |
| ISBN (Electronic) | 9780081022221 |
| ISBN (Print) | 9780081010228 |
| DOIs | |
| Publication status | Published - 1 Jan 2017 |
Keywords
- Brain repair
- Cell migration
- Electrospun scaffold
- In vitro model
- Neural tissue engineering
- Neurite outgrowth
- Surface functionalization
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