Electrospun scaffolds for neural tissue engineering

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2 Citations (Scopus)

Abstract

Regeneration of the brain following injury is often slow or ineffective due to a dearth of cellular cues that support and guide neural regeneration. Scaffolds have been actively investigated for new therapies targeting neurodegenerative diseases and traumatic brain injury. Electrospinning offers many advantages for the fabrication of a diverse and tunable range of neural scaffolds. The architecture of electrospun scaffolds can be tailored to meet specific requirements such as the culture of different types of neural cells and the incorporation and delivery of bioactive molecules. Electrospun fibers have been highly successful in providing both biological and physical cues to repair the injured brain. This chapter provides an overview of the design principles of electrospun scaffolds for neural tissue engineering, with a focus on brain repair.

Original languageEnglish
Title of host publicationElectrospun Materials for Tissue Engineering and Biomedical Applications
Subtitle of host publicationResearch, Design and Commercialization
EditorsTamer Uyar, Erich Kny
Place of PublicationDuxford UK
PublisherWoodhead Publishing Limited
Chapter13
Pages299-320
Number of pages22
ISBN (Electronic)9780081022221
ISBN (Print)9780081010228
DOIs
Publication statusPublished - 1 Jan 2017

Keywords

  • Brain repair
  • Cell migration
  • Electrospun scaffold
  • In vitro model
  • Neural tissue engineering
  • Neurite outgrowth
  • Surface functionalization

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