Electrophysiological biomarkers of epileptogenicity after traumatic brain injury

Piero Perucca, Gregory Smith, Cesar Santana-Gomez, Anatol Bragin, Richard Staba

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Post-traumatic epilepsy is the architype of acquired epilepsies, wherein a brain insult initiates an epileptogenic process culminating in an unprovoked seizure after weeks, months or years. Identifying biomarkers of such process is a prerequisite for developing and implementing targeted therapies aimed at preventing the development of epilepsy. Currently, there are no validated electrophysiological biomarkers of post-traumatic epileptogenesis. Experimental EEG studies using the lateral fluid percussion injury model have identified three candidate biomarkers of post-traumatic epileptogenesis: pathological high-frequency oscillations (HFOs, 80–300 Hz); repetitive HFOs and spikes (rHFOSs); and reduction in sleep spindle duration and dominant frequency at the transition from stage III to rapid eye movement sleep. EEG studies in humans have yielded conflicting data; recent evidence suggests that epileptiform abnormalities detected acutely after traumatic brain injury carry a significantly increased risk of subsequent epilepsy. Well-designed studies are required to validate these promising findings, and ultimately establish whether there are post-traumatic electrophysiological features which can guide the development of ‘antiepileptogenic’ therapies.

Original languageEnglish
Pages (from-to)69-74
Number of pages6
JournalNeurobiology of Disease
Volume123
DOIs
Publication statusPublished - Mar 2019

Keywords

  • Biomarker
  • EEG
  • Electrophysiology
  • Epileptogenesis
  • High-frequency oscillations
  • Post-traumatic epilepsy
  • Repetitive HFOs and spikes
  • Seizure
  • Sleep spindles
  • Traumatic brain injury

Cite this

Perucca, Piero ; Smith, Gregory ; Santana-Gomez, Cesar ; Bragin, Anatol ; Staba, Richard. / Electrophysiological biomarkers of epileptogenicity after traumatic brain injury. In: Neurobiology of Disease. 2019 ; Vol. 123. pp. 69-74.
@article{f04cb5fd08784d50a56cbfa2dfc358ad,
title = "Electrophysiological biomarkers of epileptogenicity after traumatic brain injury",
abstract = "Post-traumatic epilepsy is the architype of acquired epilepsies, wherein a brain insult initiates an epileptogenic process culminating in an unprovoked seizure after weeks, months or years. Identifying biomarkers of such process is a prerequisite for developing and implementing targeted therapies aimed at preventing the development of epilepsy. Currently, there are no validated electrophysiological biomarkers of post-traumatic epileptogenesis. Experimental EEG studies using the lateral fluid percussion injury model have identified three candidate biomarkers of post-traumatic epileptogenesis: pathological high-frequency oscillations (HFOs, 80–300 Hz); repetitive HFOs and spikes (rHFOSs); and reduction in sleep spindle duration and dominant frequency at the transition from stage III to rapid eye movement sleep. EEG studies in humans have yielded conflicting data; recent evidence suggests that epileptiform abnormalities detected acutely after traumatic brain injury carry a significantly increased risk of subsequent epilepsy. Well-designed studies are required to validate these promising findings, and ultimately establish whether there are post-traumatic electrophysiological features which can guide the development of ‘antiepileptogenic’ therapies.",
keywords = "Biomarker, EEG, Electrophysiology, Epileptogenesis, High-frequency oscillations, Post-traumatic epilepsy, Repetitive HFOs and spikes, Seizure, Sleep spindles, Traumatic brain injury",
author = "Piero Perucca and Gregory Smith and Cesar Santana-Gomez and Anatol Bragin and Richard Staba",
year = "2019",
month = "3",
doi = "10.1016/j.nbd.2018.06.002",
language = "English",
volume = "123",
pages = "69--74",
journal = "Neurobiology of Disease",
issn = "0969-9961",
publisher = "Elsevier",

}

Electrophysiological biomarkers of epileptogenicity after traumatic brain injury. / Perucca, Piero; Smith, Gregory; Santana-Gomez, Cesar; Bragin, Anatol; Staba, Richard.

In: Neurobiology of Disease, Vol. 123, 03.2019, p. 69-74.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - Electrophysiological biomarkers of epileptogenicity after traumatic brain injury

AU - Perucca, Piero

AU - Smith, Gregory

AU - Santana-Gomez, Cesar

AU - Bragin, Anatol

AU - Staba, Richard

PY - 2019/3

Y1 - 2019/3

N2 - Post-traumatic epilepsy is the architype of acquired epilepsies, wherein a brain insult initiates an epileptogenic process culminating in an unprovoked seizure after weeks, months or years. Identifying biomarkers of such process is a prerequisite for developing and implementing targeted therapies aimed at preventing the development of epilepsy. Currently, there are no validated electrophysiological biomarkers of post-traumatic epileptogenesis. Experimental EEG studies using the lateral fluid percussion injury model have identified three candidate biomarkers of post-traumatic epileptogenesis: pathological high-frequency oscillations (HFOs, 80–300 Hz); repetitive HFOs and spikes (rHFOSs); and reduction in sleep spindle duration and dominant frequency at the transition from stage III to rapid eye movement sleep. EEG studies in humans have yielded conflicting data; recent evidence suggests that epileptiform abnormalities detected acutely after traumatic brain injury carry a significantly increased risk of subsequent epilepsy. Well-designed studies are required to validate these promising findings, and ultimately establish whether there are post-traumatic electrophysiological features which can guide the development of ‘antiepileptogenic’ therapies.

AB - Post-traumatic epilepsy is the architype of acquired epilepsies, wherein a brain insult initiates an epileptogenic process culminating in an unprovoked seizure after weeks, months or years. Identifying biomarkers of such process is a prerequisite for developing and implementing targeted therapies aimed at preventing the development of epilepsy. Currently, there are no validated electrophysiological biomarkers of post-traumatic epileptogenesis. Experimental EEG studies using the lateral fluid percussion injury model have identified three candidate biomarkers of post-traumatic epileptogenesis: pathological high-frequency oscillations (HFOs, 80–300 Hz); repetitive HFOs and spikes (rHFOSs); and reduction in sleep spindle duration and dominant frequency at the transition from stage III to rapid eye movement sleep. EEG studies in humans have yielded conflicting data; recent evidence suggests that epileptiform abnormalities detected acutely after traumatic brain injury carry a significantly increased risk of subsequent epilepsy. Well-designed studies are required to validate these promising findings, and ultimately establish whether there are post-traumatic electrophysiological features which can guide the development of ‘antiepileptogenic’ therapies.

KW - Biomarker

KW - EEG

KW - Electrophysiology

KW - Epileptogenesis

KW - High-frequency oscillations

KW - Post-traumatic epilepsy

KW - Repetitive HFOs and spikes

KW - Seizure

KW - Sleep spindles

KW - Traumatic brain injury

UR - http://www.scopus.com/inward/record.url?scp=85048250301&partnerID=8YFLogxK

U2 - 10.1016/j.nbd.2018.06.002

DO - 10.1016/j.nbd.2018.06.002

M3 - Review Article

VL - 123

SP - 69

EP - 74

JO - Neurobiology of Disease

JF - Neurobiology of Disease

SN - 0969-9961

ER -