Electrophilic Activation of P-Alkynes in the Synthesis of P-Substituted and P-Centered Heterocycles

Akhil Gupta, Bernard L. Flynn

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15 Citations (Scopus)


Electrophilic activation of alkynylphosphine oxides and phosphonates provides a novel approach to the synthesis of P-substituted and P-centered heterocycles. Iodocyclization affords a heteroaryl iodide that can, among other things, be used in reiterative alkyne coupling and iodocyclization to give cyclic phosphonates and other cyclization reactions to give π-rich P-heterocycles.

Original languageEnglish
Pages (from-to)4012-4019
Number of pages8
JournalThe Journal of Organic Chemistry
Issue number10
Publication statusPublished - 20 May 2016

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