Electrooxidation mechanism of non-steroidal anti-inflammatory drug piroxicam at glassy carbon electrode

The electrochem. oxidn. behavior of the antiinflammatory drug piroxicam at the glassy C electrode in 10 MeCN + 90 0.2M Britton-Robinson Buffer is presented. Cyclic voltammetry, controlled potential electrolysis and spectroscopic techniques were used to obtain information about the reaction mechanism and product identification. After exhaustive electrolysis, the extn. followed by chromatog. sepn. of the reaction products gave the oxidized compds. Using UV-visible, GC-MS, 1H and 13C NMR techniques as well as the results of the preceding electrochem. study, 2- [(carboxycarbonyl)(methyl)amino]sulfonyl benzoic acid and 2-aminopyridine were identified. To account for the formation of these products, a detailed interpretation of the mechanism of the electrooxidn. of piroxicam in acidic-buffered media is presented. [on SciFinder (R)]