Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 4058 - 4060 |
| Number of pages | 3 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 57 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2013 |
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Electronic estimations of renal function are inaccurate in solid-organ transplant recipients and can result in significant underdosing of prophylactic valganciclovir. / Trevillyan, Janine Maree; Angus, Peter W; Shelton, Edward; Whitlam, J; Ierino, Francesco L; Pavlovic, Julia; Gregory, D; Urbancic, Karen Frances; Torresi, Joseph; Testro, Adam G; Grayson, M Lindsay.
In: Antimicrobial Agents and Chemotherapy, Vol. 57, No. 8, 2013, p. 4058 - 4060.Research output: Contribution to journal › Article › Other › peer-review
TY - JOUR
T1 - Electronic estimations of renal function are inaccurate in solid-organ transplant recipients and can result in significant underdosing of prophylactic valganciclovir
AU - Trevillyan, Janine Maree
AU - Angus, Peter W
AU - Shelton, Edward
AU - Whitlam, J
AU - Ierino, Francesco L
AU - Pavlovic, Julia
AU - Gregory, D
AU - Urbancic, Karen Frances
AU - Torresi, Joseph
AU - Testro, Adam G
AU - Grayson, M Lindsay
PY - 2013
Y1 - 2013
N2 - In a prospective study of solid-organ transplant recipients (n 22; 15 hepatic and 7 renal) receiving valganciclovir for cytomegalovirus (CMV) prophylaxis, electronic estimation of glomerular filtration rate (eGFR) underestimated the true GFR (24-h urine creatinine clearance) by>20 in 14/22 (63.6 ). Its use was associated with inappropriate underdosing of valganciclovir, while the Cockroft-Gault equation was accurate in 21/22 patients (95.4 ). Subtherapeutic ganciclovir levels (
AB - In a prospective study of solid-organ transplant recipients (n 22; 15 hepatic and 7 renal) receiving valganciclovir for cytomegalovirus (CMV) prophylaxis, electronic estimation of glomerular filtration rate (eGFR) underestimated the true GFR (24-h urine creatinine clearance) by>20 in 14/22 (63.6 ). Its use was associated with inappropriate underdosing of valganciclovir, while the Cockroft-Gault equation was accurate in 21/22 patients (95.4 ). Subtherapeutic ganciclovir levels (
UR - http://aac.asm.org/content/57/8/4058.full.pdf
U2 - 10.1128/AAC.00375-13
DO - 10.1128/AAC.00375-13
M3 - Article
VL - 57
SP - 4058
EP - 4060
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 1098-6596
IS - 8
ER -