Electronic estimations of renal function are inaccurate in solid-organ transplant recipients and can result in significant underdosing of prophylactic valganciclovir

Janine Maree Trevillyan; Peter W Angus; Edward Shelton; J Whitlam; Francesco L Ierino; Julia Pavlovic; D Gregory; Karen Frances Urbancic; Joseph Torresi; Adam G Testro; M Lindsay Grayson

doi:10.1128/AAC.00375-13

Electronic estimations of renal function are inaccurate in solid-organ transplant recipients and can result in significant underdosing of prophylactic valganciclovir

Janine Maree Trevillyan, Peter W Angus, Edward Shelton, J Whitlam, Francesco L Ierino, Julia Pavlovic, D Gregory, Karen Frances Urbancic, Joseph Torresi, Adam G Testro, M Lindsay Grayson

Epidemiology and Preventive Medicine Alfred Hospital

Research output: Contribution to journal › Article › Other › peer-review

11 Citations (Scopus)

Abstract

In a prospective study of solid-organ transplant recipients (n 22; 15 hepatic and 7 renal) receiving valganciclovir for cytomegalovirus (CMV) prophylaxis, electronic estimation of glomerular filtration rate (eGFR) underestimated the true GFR (24-h urine creatinine clearance) by>20 in 14/22 (63.6 ). Its use was associated with inappropriate underdosing of valganciclovir, while the Cockroft-Gault equation was accurate in 21/22 patients (95.4 ). Subtherapeutic ganciclovir levels (

Original language	English
Pages (from-to)	4058 - 4060
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	57
Issue number	8
DOIs	https://doi.org/10.1128/AAC.00375-13
Publication status	Published - 2013

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Trevillyan, J. M., Angus, P. W., Shelton, E., Whitlam, J., Ierino, F. L., Pavlovic, J., Gregory, D., Urbancic, K. F., Torresi, J., Testro, A. G., & Grayson, M. L. (2013). Electronic estimations of renal function are inaccurate in solid-organ transplant recipients and can result in significant underdosing of prophylactic valganciclovir. Antimicrobial Agents and Chemotherapy, 57(8), 4058 - 4060. https://doi.org/10.1128/AAC.00375-13

Trevillyan, Janine Maree ; Angus, Peter W ; Shelton, Edward ; Whitlam, J ; Ierino, Francesco L ; Pavlovic, Julia ; Gregory, D ; Urbancic, Karen Frances ; Torresi, Joseph ; Testro, Adam G ; Grayson, M Lindsay. / Electronic estimations of renal function are inaccurate in solid-organ transplant recipients and can result in significant underdosing of prophylactic valganciclovir. In: Antimicrobial Agents and Chemotherapy. 2013 ; Vol. 57, No. 8. pp. 4058 - 4060.

@article{ab30ac6ff05e4cc5b188de0aa7f6e40c,

title = "Electronic estimations of renal function are inaccurate in solid-organ transplant recipients and can result in significant underdosing of prophylactic valganciclovir",

abstract = "In a prospective study of solid-organ transplant recipients (n 22; 15 hepatic and 7 renal) receiving valganciclovir for cytomegalovirus (CMV) prophylaxis, electronic estimation of glomerular filtration rate (eGFR) underestimated the true GFR (24-h urine creatinine clearance) by>20 in 14/22 (63.6 ). Its use was associated with inappropriate underdosing of valganciclovir, while the Cockroft-Gault equation was accurate in 21/22 patients (95.4 ). Subtherapeutic ganciclovir levels (",

author = "Trevillyan, {Janine Maree} and Angus, {Peter W} and Edward Shelton and J Whitlam and Ierino, {Francesco L} and Julia Pavlovic and D Gregory and Urbancic, {Karen Frances} and Joseph Torresi and Testro, {Adam G} and Grayson, {M Lindsay}",

year = "2013",

doi = "10.1128/AAC.00375-13",

language = "English",

volume = "57",

pages = "4058 -- 4060",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

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}

Trevillyan, JM, Angus, PW, Shelton, E, Whitlam, J, Ierino, FL, Pavlovic, J, Gregory, D, Urbancic, KF, Torresi, J, Testro, AG & Grayson, ML 2013, 'Electronic estimations of renal function are inaccurate in solid-organ transplant recipients and can result in significant underdosing of prophylactic valganciclovir', Antimicrobial Agents and Chemotherapy, vol. 57, no. 8, pp. 4058 - 4060. https://doi.org/10.1128/AAC.00375-13

Electronic estimations of renal function are inaccurate in solid-organ transplant recipients and can result in significant underdosing of prophylactic valganciclovir. / Trevillyan, Janine Maree; Angus, Peter W; Shelton, Edward; Whitlam, J; Ierino, Francesco L; Pavlovic, Julia; Gregory, D; Urbancic, Karen Frances; Torresi, Joseph; Testro, Adam G; Grayson, M Lindsay.

In: Antimicrobial Agents and Chemotherapy, Vol. 57, No. 8, 2013, p. 4058 - 4060.

Research output: Contribution to journal › Article › Other › peer-review

TY - JOUR

T1 - Electronic estimations of renal function are inaccurate in solid-organ transplant recipients and can result in significant underdosing of prophylactic valganciclovir

AU - Trevillyan, Janine Maree

AU - Angus, Peter W

AU - Shelton, Edward

AU - Whitlam, J

AU - Ierino, Francesco L

AU - Pavlovic, Julia

AU - Gregory, D

AU - Urbancic, Karen Frances

AU - Torresi, Joseph

AU - Testro, Adam G

AU - Grayson, M Lindsay

PY - 2013

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AB - In a prospective study of solid-organ transplant recipients (n 22; 15 hepatic and 7 renal) receiving valganciclovir for cytomegalovirus (CMV) prophylaxis, electronic estimation of glomerular filtration rate (eGFR) underestimated the true GFR (24-h urine creatinine clearance) by>20 in 14/22 (63.6 ). Its use was associated with inappropriate underdosing of valganciclovir, while the Cockroft-Gault equation was accurate in 21/22 patients (95.4 ). Subtherapeutic ganciclovir levels (

UR - http://aac.asm.org/content/57/8/4058.full.pdf

U2 - 10.1128/AAC.00375-13

DO - 10.1128/AAC.00375-13

M3 - Article

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SP - 4058

EP - 4060

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 8

ER -

Electronic estimations of renal function are inaccurate in solid-organ transplant recipients and can result in significant underdosing of prophylactic valganciclovir

Abstract

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