Electronic estimations of renal function are inaccurate in solid-organ transplant recipients and can result in significant underdosing of prophylactic valganciclovir

Janine Maree Trevillyan, Peter W Angus, Edward Shelton, J Whitlam, Francesco L Ierino, Julia Pavlovic, D Gregory, Karen Frances Urbancic, Joseph Torresi, Adam G Testro, M Lindsay Grayson

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9 Citations (Scopus)

Abstract

In a prospective study of solid-organ transplant recipients (n 22; 15 hepatic and 7 renal) receiving valganciclovir for cytomegalovirus (CMV) prophylaxis, electronic estimation of glomerular filtration rate (eGFR) underestimated the true GFR (24-h urine creatinine clearance) by>20 in 14/22 (63.6 ). Its use was associated with inappropriate underdosing of valganciclovir, while the Cockroft-Gault equation was accurate in 21/22 patients (95.4 ). Subtherapeutic ganciclovir levels (
Original languageEnglish
Pages (from-to)4058 - 4060
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume57
Issue number8
DOIs
Publication statusPublished - 2013

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