Electronic estimations of renal function are inaccurate in solid-organ transplant recipients and can result in significant underdosing of prophylactic valganciclovir

Janine Maree Trevillyan, Peter W Angus, Edward Shelton, J Whitlam, Francesco L Ierino, Julia Pavlovic, D Gregory, Karen Frances Urbancic, Joseph Torresi, Adam G Testro, M Lindsay Grayson

Research output: Contribution to journalArticleOtherpeer-review

8 Citations (Scopus)

Abstract

In a prospective study of solid-organ transplant recipients (n 22; 15 hepatic and 7 renal) receiving valganciclovir for cytomegalovirus (CMV) prophylaxis, electronic estimation of glomerular filtration rate (eGFR) underestimated the true GFR (24-h urine creatinine clearance) by>20 in 14/22 (63.6 ). Its use was associated with inappropriate underdosing of valganciclovir, while the Cockroft-Gault equation was accurate in 21/22 patients (95.4 ). Subtherapeutic ganciclovir levels (
Original languageEnglish
Pages (from-to)4058 - 4060
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume57
Issue number8
DOIs
Publication statusPublished - 2013

Cite this

Trevillyan, Janine Maree ; Angus, Peter W ; Shelton, Edward ; Whitlam, J ; Ierino, Francesco L ; Pavlovic, Julia ; Gregory, D ; Urbancic, Karen Frances ; Torresi, Joseph ; Testro, Adam G ; Grayson, M Lindsay. / Electronic estimations of renal function are inaccurate in solid-organ transplant recipients and can result in significant underdosing of prophylactic valganciclovir. In: Antimicrobial Agents and Chemotherapy. 2013 ; Vol. 57, No. 8. pp. 4058 - 4060.
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abstract = "In a prospective study of solid-organ transplant recipients (n 22; 15 hepatic and 7 renal) receiving valganciclovir for cytomegalovirus (CMV) prophylaxis, electronic estimation of glomerular filtration rate (eGFR) underestimated the true GFR (24-h urine creatinine clearance) by>20 in 14/22 (63.6 ). Its use was associated with inappropriate underdosing of valganciclovir, while the Cockroft-Gault equation was accurate in 21/22 patients (95.4 ). Subtherapeutic ganciclovir levels (",
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Electronic estimations of renal function are inaccurate in solid-organ transplant recipients and can result in significant underdosing of prophylactic valganciclovir. / Trevillyan, Janine Maree; Angus, Peter W; Shelton, Edward; Whitlam, J; Ierino, Francesco L; Pavlovic, Julia; Gregory, D; Urbancic, Karen Frances; Torresi, Joseph; Testro, Adam G; Grayson, M Lindsay.

In: Antimicrobial Agents and Chemotherapy, Vol. 57, No. 8, 2013, p. 4058 - 4060.

Research output: Contribution to journalArticleOtherpeer-review

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AU - Whitlam, J

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