Electromechanics modeling of the effects of myocardial infarction on left ventricular function

Chin Neng Leong, Amr Al Abed, Einly Lim, Nigel Hamilton Lovell, Silvana Marasco, Shahrul A. Hashim, Socrates Dokos

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Abstract

Ventricular remodeling may occur following myocardial infarction of the left ventricle (LV) and such remodeling has been shown to be correlated with increased patient morbidity and mortality. It is thus important to estimate the likelihood of remodeling from the state of the infarcted LV. In this paper, we present simulations from an actively-contracting truncated ellipsoid LV model, incorporating realistic fiber orientation and electromechanical properties, to investigate the effects of infarct size and transmural extent (TME) on myofiber regional mechanics. Results showed that transmural infarcts greatly elevated both the myofiber stress and strain at the border zone during end systole, making the LV more susceptible to structural remodeling. It was found that TME rather than infarct size was more predictive of LV remodeling.

Original languageEnglish
Title of host publication2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2015)
EditorsJim Patton
Place of PublicationPiscataway NJ USA
PublisherIEEE, Institute of Electrical and Electronics Engineers
Pages5684-5687
Number of pages4
ISBN (Electronic)9781424492718
ISBN (Print)9781424492695
DOIs
Publication statusPublished - 5 Nov 2015
Externally publishedYes
EventInternational Conference of the IEEE Engineering in Medicine and Biology Society 2015 - Milan, Italy
Duration: 25 Aug 201529 Aug 2015
Conference number: 37th
https://embc.embs.org/2015/
https://ieeexplore.ieee.org/xpl/conhome/7302811/proceeding (Proceedings)

Conference

ConferenceInternational Conference of the IEEE Engineering in Medicine and Biology Society 2015
Abbreviated titleEMBC 2015
CountryItaly
CityMilan
Period25/08/1529/08/15
Other37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS). Our Annual Conference (known as EMBC) is a premier international conference in biomedical engineering, and has been strategically held in different locations around the world, including Chicago, Osaka, San Diego, Boston, Buenos Aires, Minneapolis, Vancouver, Lyon, New York, and Shanghai over the last 10 years.
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