Electromechanics modeling of the effects of myocardial infarction on left ventricular function

Chin Neng Leong; Amr Al Abed; Einly Lim; Nigel Hamilton Lovell; Silvana Marasco; Shahrul A. Hashim; Socrates Dokos

doi:10.1109/EMBC.2015.7319682

Electromechanics modeling of the effects of myocardial infarction on left ventricular function

Chin Neng Leong, Amr Al Abed, Einly Lim, Nigel Hamilton Lovell, Silvana Marasco, Shahrul A. Hashim, Socrates Dokos

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

3 Citations (Scopus)

Abstract

Ventricular remodeling may occur following myocardial infarction of the left ventricle (LV) and such remodeling has been shown to be correlated with increased patient morbidity and mortality. It is thus important to estimate the likelihood of remodeling from the state of the infarcted LV. In this paper, we present simulations from an actively-contracting truncated ellipsoid LV model, incorporating realistic fiber orientation and electromechanical properties, to investigate the effects of infarct size and transmural extent (TME) on myofiber regional mechanics. Results showed that transmural infarcts greatly elevated both the myofiber stress and strain at the border zone during end systole, making the LV more susceptible to structural remodeling. It was found that TME rather than infarct size was more predictive of LV remodeling.

Original language	English
Title of host publication	2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2015)
Editors	Jim Patton
Place of Publication	Piscataway NJ USA
Publisher	IEEE, Institute of Electrical and Electronics Engineers
Pages	5684-5687
Number of pages	4
ISBN (Electronic)	9781424492718
ISBN (Print)	9781424492695
DOIs	https://doi.org/10.1109/EMBC.2015.7319682
Publication status	Published - 5 Nov 2015
Externally published	Yes
Event	International Conference of the IEEE Engineering in Medicine and Biology Society 2015 - Milan, Italy Duration: 25 Aug 2015 → 29 Aug 2015 Conference number: 37th https://embc.embs.org/2015/ https://ieeexplore.ieee.org/xpl/conhome/7302811/proceeding (Proceedings)

Conference

Conference	International Conference of the IEEE Engineering in Medicine and Biology Society 2015
Abbreviated title	EMBC 2015
Country/Territory	Italy
City	Milan
Period	25/08/15 → 29/08/15
Internet address	https://embc.embs.org/2015/ https://ieeexplore.ieee.org/xpl/conhome/7302811/proceeding (Proceedings)

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10.1109/EMBC.2015.7319682

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Leong, C. N., Al Abed, A., Lim, E., Lovell, N. H., Marasco, S., Hashim, S. A., & Dokos, S. (2015). Electromechanics modeling of the effects of myocardial infarction on left ventricular function. In J. Patton (Ed.), 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2015) (pp. 5684-5687). Article 7319682 IEEE, Institute of Electrical and Electronics Engineers. https://doi.org/10.1109/EMBC.2015.7319682

Leong, Chin Neng ; Al Abed, Amr ; Lim, Einly et al. / Electromechanics modeling of the effects of myocardial infarction on left ventricular function. 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2015). editor / Jim Patton. Piscataway NJ USA : IEEE, Institute of Electrical and Electronics Engineers, 2015. pp. 5684-5687

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title = "Electromechanics modeling of the effects of myocardial infarction on left ventricular function",

abstract = "Ventricular remodeling may occur following myocardial infarction of the left ventricle (LV) and such remodeling has been shown to be correlated with increased patient morbidity and mortality. It is thus important to estimate the likelihood of remodeling from the state of the infarcted LV. In this paper, we present simulations from an actively-contracting truncated ellipsoid LV model, incorporating realistic fiber orientation and electromechanical properties, to investigate the effects of infarct size and transmural extent (TME) on myofiber regional mechanics. Results showed that transmural infarcts greatly elevated both the myofiber stress and strain at the border zone during end systole, making the LV more susceptible to structural remodeling. It was found that TME rather than infarct size was more predictive of LV remodeling.",

author = "Leong, {Chin Neng} and {Al Abed}, Amr and Einly Lim and Lovell, {Nigel Hamilton} and Silvana Marasco and Hashim, {Shahrul A.} and Socrates Dokos",

year = "2015",

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doi = "10.1109/EMBC.2015.7319682",

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booktitle = "2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2015)",

publisher = "IEEE, Institute of Electrical and Electronics Engineers",

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note = "International Conference of the IEEE Engineering in Medicine and Biology Society 2015, EMBC 2015 ; Conference date: 25-08-2015 Through 29-08-2015",

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Leong, CN, Al Abed, A, Lim, E, Lovell, NH, Marasco, S, Hashim, SA & Dokos, S 2015, Electromechanics modeling of the effects of myocardial infarction on left ventricular function. in J Patton (ed.), 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2015)., 7319682, IEEE, Institute of Electrical and Electronics Engineers, Piscataway NJ USA, pp. 5684-5687, International Conference of the IEEE Engineering in Medicine and Biology Society 2015, Milan, Italy, 25/08/15. https://doi.org/10.1109/EMBC.2015.7319682

Electromechanics modeling of the effects of myocardial infarction on left ventricular function. / Leong, Chin Neng; Al Abed, Amr; Lim, Einly et al.
2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2015). ed. / Jim Patton. Piscataway NJ USA: IEEE, Institute of Electrical and Electronics Engineers, 2015. p. 5684-5687 7319682.

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

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T1 - Electromechanics modeling of the effects of myocardial infarction on left ventricular function

AU - Leong, Chin Neng

AU - Al Abed, Amr

AU - Lim, Einly

AU - Lovell, Nigel Hamilton

AU - Marasco, Silvana

AU - Hashim, Shahrul A.

AU - Dokos, Socrates

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PY - 2015/11/5

Y1 - 2015/11/5

N2 - Ventricular remodeling may occur following myocardial infarction of the left ventricle (LV) and such remodeling has been shown to be correlated with increased patient morbidity and mortality. It is thus important to estimate the likelihood of remodeling from the state of the infarcted LV. In this paper, we present simulations from an actively-contracting truncated ellipsoid LV model, incorporating realistic fiber orientation and electromechanical properties, to investigate the effects of infarct size and transmural extent (TME) on myofiber regional mechanics. Results showed that transmural infarcts greatly elevated both the myofiber stress and strain at the border zone during end systole, making the LV more susceptible to structural remodeling. It was found that TME rather than infarct size was more predictive of LV remodeling.

AB - Ventricular remodeling may occur following myocardial infarction of the left ventricle (LV) and such remodeling has been shown to be correlated with increased patient morbidity and mortality. It is thus important to estimate the likelihood of remodeling from the state of the infarcted LV. In this paper, we present simulations from an actively-contracting truncated ellipsoid LV model, incorporating realistic fiber orientation and electromechanical properties, to investigate the effects of infarct size and transmural extent (TME) on myofiber regional mechanics. Results showed that transmural infarcts greatly elevated both the myofiber stress and strain at the border zone during end systole, making the LV more susceptible to structural remodeling. It was found that TME rather than infarct size was more predictive of LV remodeling.

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BT - 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2015)

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Leong CN, Al Abed A, Lim E, Lovell NH, Marasco S, Hashim SA et al. Electromechanics modeling of the effects of myocardial infarction on left ventricular function. In Patton J, editor, 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2015). Piscataway NJ USA: IEEE, Institute of Electrical and Electronics Engineers. 2015. p. 5684-5687. 7319682 doi: 10.1109/EMBC.2015.7319682

Electromechanics modeling of the effects of myocardial infarction on left ventricular function

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