Electrochemical Behavior and Redox-Dependent Disassembly of Gallic Acid/FeIII Metal-Phenolic Networks

Pavel V. Cherepanov, Md Arifur Rahim, Nadja Bertleff-Zieschang, Md Abu Sayeed, Anthony P. O'Mullane, Simon E. Moulton, Frank Caruso

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)


Metal-phenolic networks (MPNs) are a versatile class of organic-inorganic hybrid systems that are generating interest for applications in catalysis, bioimaging, and drug delivery. These self-assembled MPNs possess metal-coordinated structures and may potentially serve as redox-responsive platforms for triggered disassembly or drug release. Therefore, a comprehensive study of the reduction and oxidation behavior of MPNs for evaluating their redox responsiveness, specific conditions required for their disassembly, and the kinetics of metal ion release, is necessary. Using a representative MPN gallic acid-iron (GA/FeIII) system, we conducted electrochemical studies to provide fundamental insights into the redox behavior of these MPNs. We demonstrate that GA/FeIII is redox active, and evaluate its electrochemical reversibility, identify the oxidation state of the redox-active species, and provide information regarding the stability of the networks toward reductive stimuli and specific redox conditions required for the "on-off" or continuous release of FeIII. Overall, through studying the redox properties of GA/FeIII films, we advance the understanding of multifunctional iron-containing MPN platforms that may have practical significance for biologically relevant applications.

Original languageEnglish
Pages (from-to)5828-5834
Number of pages7
JournalACS Applied Materials & Interfaces
Issue number6
Publication statusPublished - 14 Feb 2018
Externally publishedYes


  • coordination complexes
  • electrochemical disassembly
  • metal-phenolic networks
  • organic-inorganic hybrid
  • phenolic ligands
  • redox response

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