Electrochemical aptamer-based sensors

Beatriz Prieto-Simón, Mònica Campàs, Jean Louis Marty

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Abstract

The valuable properties of aptamers, such as specificity, sensitivity, stability, cost-effectiveness and design flexibility, have favoured their use as biorecognition elements in biosensor development. These synthetic affinity probes can be developed for almost any target molecule, covering a wide range of applications in fields such as clinical diagnosis and therapy, environmental monitoring and food control. The combination of aptamers with high-performance electrochemical transducers, with their inherent high sensitivities, fast response times and simple equipment, has already provided several electrochemical aptamer-based sensors. Moreover, the small size and versatility of aptamers allow efficient immobilisations in high-density monolayers, an important feature towards miniaturisation and integration of compact electrochemical devices. This review describes the state-of-the-art of electrochemical aptamer-based sensors, entering into the details of the different strategies and types of electrochemical transduction and also considering their advantages when applied to the analysis of complex matrices.

Original languageEnglish
Pages (from-to)141-157
Number of pages17
JournalBioanalytical Reviews
Volume1
Issue number2
DOIs
Publication statusPublished - 2010
Externally publishedYes

Keywords

  • Aptabeacon
  • Aptamer
  • Biosensor
  • Electrochemical detection
  • Redox label

Cite this

Prieto-Simón, B., Campàs, M., & Marty, J. L. (2010). Electrochemical aptamer-based sensors. Bioanalytical Reviews, 1(2), 141-157. https://doi.org/10.1007/s12566-010-0010-1