Elderly patients and intra-arterial stroke therapy

Thabele M Leslie-Mazwi, Ronil V. Chandra, Claus Ziegler Simonsen, Albert J Yoo

Research output: Contribution to journalReview ArticleOtherpeer-review

1 Citation (Scopus)


Ischemic stroke disproportionately affects the elderly, particularly those over the age of 80 years. Rates of stroke are expected to increase over the next several decades due to increasing numbers of elderly individuals, making understanding stroke treatment in this population an imperative. The only proven acute stroke therapy is early reperfusion, accomplished through intravenous or intra-arterial means. Intra-arterial stroke therapy (IAT) offers higher recanalization rates than intravenous tissue plasminogen activator, but has yet to show clear superiority over intravenous tissue plasminogen activator alone. Existing data suggest that elderly stroke patients suffer worse outcomes following IAT, despite similar rates of recanalization and symptomatic intracranial hemorrhage. This article reviews the application of IAT in the elderly population and summarizes the available studies that investigate the response of elderly patients to IAT.

Original languageEnglish
Pages (from-to)1713-1723
Number of pages11
JournalExpert Review of Cardiovascular Therapy
Issue number12
Publication statusPublished - 2013
Externally publishedYes


  • Elderly
  • Intra-arterial
  • Stroke
  • Thrombolytic therapy

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