Tumor cells are dependent on high protein synthesis rates to fuel their neoplastic growth. eIF4E is a 5 mRNA cap-binding protein that recruits mRNA to the ribosome and exhibits oncogenic properties. Mitogens, nutrients and growth factors stimulate the MAPK and PI3K pathways that converge on eIF4E. eIF4E is phosphorylated by the MNKs at a single site (Ser209 in mammals), which stimulates translation of a subset of tumor-promoting mRNAs, thereby bolstering its oncogenic properties. In this chapter, we will discuss the molecular mechanisms underlying the role of eIF4E phosphorylation in neoplasia and its potential clinical applications.
|Title of host publication||Translation and Its Regulation in Cancer Biology and Medicine|
|Place of Publication||The Netherlands|
|Pages||363 - 374|
|Number of pages||12|
|Publication status||Published - 2014|