eIF4E phosphorylation downstream of MAPK pathway

Luc Furic; Emma Kate Beardsley; Ivan Topisirovic

doi:10.1007/978-94-017-9078-9_17

eIF4E phosphorylation downstream of MAPK pathway

Luc Furic, Emma Kate Beardsley, Ivan Topisirovic

Anatomy & Developmental Biology

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review

1 Citation (Scopus)

Abstract

Tumor cells are dependent on high protein synthesis rates to fuel their neoplastic growth. eIF4E is a 5 mRNA cap-binding protein that recruits mRNA to the ribosome and exhibits oncogenic properties. Mitogens, nutrients and growth factors stimulate the MAPK and PI3K pathways that converge on eIF4E. eIF4E is phosphorylated by the MNKs at a single site (Ser209 in mammals), which stimulates translation of a subset of tumor-promoting mRNAs, thereby bolstering its oncogenic properties. In this chapter, we will discuss the molecular mechanisms underlying the role of eIF4E phosphorylation in neoplasia and its potential clinical applications.

Original language	English
Title of host publication	Translation and Its Regulation in Cancer Biology and Medicine
Editors	Armen Parsyan
Place of Publication	The Netherlands
Publisher	Springer
Pages	363 - 374
Number of pages	12
Edition	1st
ISBN (Print)	9789401790772
DOIs	https://doi.org/10.1007/978-94-017-9078-9_17
Publication status	Published - 2014

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10.1007/978-94-017-9078-9_17

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abstract = "Tumor cells are dependent on high protein synthesis rates to fuel their neoplastic growth. eIF4E is a 5 mRNA cap-binding protein that recruits mRNA to the ribosome and exhibits oncogenic properties. Mitogens, nutrients and growth factors stimulate the MAPK and PI3K pathways that converge on eIF4E. eIF4E is phosphorylated by the MNKs at a single site (Ser209 in mammals), which stimulates translation of a subset of tumor-promoting mRNAs, thereby bolstering its oncogenic properties. In this chapter, we will discuss the molecular mechanisms underlying the role of eIF4E phosphorylation in neoplasia and its potential clinical applications.",

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AB - Tumor cells are dependent on high protein synthesis rates to fuel their neoplastic growth. eIF4E is a 5 mRNA cap-binding protein that recruits mRNA to the ribosome and exhibits oncogenic properties. Mitogens, nutrients and growth factors stimulate the MAPK and PI3K pathways that converge on eIF4E. eIF4E is phosphorylated by the MNKs at a single site (Ser209 in mammals), which stimulates translation of a subset of tumor-promoting mRNAs, thereby bolstering its oncogenic properties. In this chapter, we will discuss the molecular mechanisms underlying the role of eIF4E phosphorylation in neoplasia and its potential clinical applications.

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BT - Translation and Its Regulation in Cancer Biology and Medicine

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ER -

eIF4E phosphorylation downstream of MAPK pathway

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