eIF4E phosphorylation downstream of MAPK pathway

Luc Furic, Emma Kate Beardsley, Ivan Topisirovic

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Abstract

Tumor cells are dependent on high protein synthesis rates to fuel their neoplastic growth. eIF4E is a 5 mRNA cap-binding protein that recruits mRNA to the ribosome and exhibits oncogenic properties. Mitogens, nutrients and growth factors stimulate the MAPK and PI3K pathways that converge on eIF4E. eIF4E is phosphorylated by the MNKs at a single site (Ser209 in mammals), which stimulates translation of a subset of tumor-promoting mRNAs, thereby bolstering its oncogenic properties. In this chapter, we will discuss the molecular mechanisms underlying the role of eIF4E phosphorylation in neoplasia and its potential clinical applications.
Original languageEnglish
Title of host publicationTranslation and Its Regulation in Cancer Biology and Medicine
EditorsArmen Parsyan
Place of PublicationThe Netherlands
PublisherSpringer
Pages363 - 374
Number of pages12
Edition1st
ISBN (Print)9789401790772
DOIs
Publication statusPublished - 2014

Cite this

Furic, L., Beardsley, E. K., & Topisirovic, I. (2014). eIF4E phosphorylation downstream of MAPK pathway. In A. Parsyan (Ed.), Translation and Its Regulation in Cancer Biology and Medicine (1st ed., pp. 363 - 374). The Netherlands: Springer. https://doi.org/10.1007/978-94-017-9078-9_17
Furic, Luc ; Beardsley, Emma Kate ; Topisirovic, Ivan. / eIF4E phosphorylation downstream of MAPK pathway. Translation and Its Regulation in Cancer Biology and Medicine. editor / Armen Parsyan. 1st. ed. The Netherlands : Springer, 2014. pp. 363 - 374
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Furic, L, Beardsley, EK & Topisirovic, I 2014, eIF4E phosphorylation downstream of MAPK pathway. in A Parsyan (ed.), Translation and Its Regulation in Cancer Biology and Medicine. 1st edn, Springer, The Netherlands, pp. 363 - 374. https://doi.org/10.1007/978-94-017-9078-9_17

eIF4E phosphorylation downstream of MAPK pathway. / Furic, Luc; Beardsley, Emma Kate; Topisirovic, Ivan.

Translation and Its Regulation in Cancer Biology and Medicine. ed. / Armen Parsyan. 1st. ed. The Netherlands : Springer, 2014. p. 363 - 374.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

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Furic L, Beardsley EK, Topisirovic I. eIF4E phosphorylation downstream of MAPK pathway. In Parsyan A, editor, Translation and Its Regulation in Cancer Biology and Medicine. 1st ed. The Netherlands: Springer. 2014. p. 363 - 374 https://doi.org/10.1007/978-94-017-9078-9_17