Egr2 to the rescue: nanoparticles revitalize natural killer cells in the fight against cancer

Aline Pfefferle; Santosh Phuyal; Herman Netskar; Karl Johan Malmberg

doi:10.1038/s44318-024-00144-y

Egr2 to the rescue: nanoparticles revitalize natural killer cells in the fight against cancer

Aline Pfefferle, Santosh Phuyal, Herman Netskar, Karl Johan Malmberg

Research output: Contribution to journal › Comment / Debate › Other › peer-review

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Abstract

Reversal of tumor-induced natural killer (NK) cell dysfunction remains a major hurdle to overcome for the clinical success of immunotherapies based on NK cells targeting solid tumors. New research in The EMBO Journal identifies the transcription factor early growth response gene 2 (Egr2) and diacylglycerol kinase DGKα as two negative regulators of NK cell dysfunction (Sabag et al, 2024).

Original language	English
Pages (from-to)	2527-2529
Number of pages	3
Journal	The EMBO Journal
Volume	43
Issue number	13
DOIs	https://doi.org/10.1038/s44318-024-00144-y
Publication status	Published - 1 Jul 2024
Externally published	Yes

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Cite this

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abstract = "Reversal of tumor-induced natural killer (NK) cell dysfunction remains a major hurdle to overcome for the clinical success of immunotherapies based on NK cells targeting solid tumors. New research in The EMBO Journal identifies the transcription factor early growth response gene 2 (Egr2) and diacylglycerol kinase DGKα as two negative regulators of NK cell dysfunction (Sabag et al, 2024).",

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T2 - nanoparticles revitalize natural killer cells in the fight against cancer

AU - Pfefferle, Aline

AU - Phuyal, Santosh

AU - Netskar, Herman

AU - Malmberg, Karl Johan

N1 - Publisher Copyright: © The Author(s) 2024.

PY - 2024/7/1

Y1 - 2024/7/1

N2 - Reversal of tumor-induced natural killer (NK) cell dysfunction remains a major hurdle to overcome for the clinical success of immunotherapies based on NK cells targeting solid tumors. New research in The EMBO Journal identifies the transcription factor early growth response gene 2 (Egr2) and diacylglycerol kinase DGKα as two negative regulators of NK cell dysfunction (Sabag et al, 2024).

AB - Reversal of tumor-induced natural killer (NK) cell dysfunction remains a major hurdle to overcome for the clinical success of immunotherapies based on NK cells targeting solid tumors. New research in The EMBO Journal identifies the transcription factor early growth response gene 2 (Egr2) and diacylglycerol kinase DGKα as two negative regulators of NK cell dysfunction (Sabag et al, 2024).

UR - https://www.scopus.com/pages/publications/85196429365

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DO - 10.1038/s44318-024-00144-y

M3 - Comment / Debate

C2 - 38886578

AN - SCOPUS:85196429365

SN - 0261-4189

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EP - 2529

JO - The EMBO Journal

JF - The EMBO Journal

IS - 13

ER -

Egr2 to the rescue: nanoparticles revitalize natural killer cells in the fight against cancer

Abstract

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