TY - JOUR
T1 - EGF receptor-targeting peptide conjugate incorporating a near-IR fluorescent dye and a novel 1,4,7-triazacyclononane-based 64Cu(II) chelator assembled via click chemistry
AU - Viehweger, Katrin
AU - Barbaro, Lisa
AU - Pombo-Garcia, Karina
AU - Joshi, Tanmaya
AU - Geipel, Gerhard
AU - Steinbach, Jorg
AU - Stephan, Holger
AU - Spiccia, Leone
AU - Graham, Bimbil
PY - 2014
Y1 - 2014
N2 - A new Boc-protected 1,4,7-triazacyclononane (TACN)-based pro-chelator compound featuring a clickable azidomethylpyridine pendant has been developed as a building block for the construction of multimodal imaging agents. Conjugation to a model alkyne (propargyl alcohol), followed by deprotection, generates a pentadentate ligand, as confirmed by X-ray crystallographic analysis of the corresponding distorted square-pyramidal Cu(II) complex. The ligand exhibits rapid 64Cu(II)-binding kinetics (>95 radiochemical yield in
AB - A new Boc-protected 1,4,7-triazacyclononane (TACN)-based pro-chelator compound featuring a clickable azidomethylpyridine pendant has been developed as a building block for the construction of multimodal imaging agents. Conjugation to a model alkyne (propargyl alcohol), followed by deprotection, generates a pentadentate ligand, as confirmed by X-ray crystallographic analysis of the corresponding distorted square-pyramidal Cu(II) complex. The ligand exhibits rapid 64Cu(II)-binding kinetics (>95 radiochemical yield in
UR - http://pubs.acs.org/doi/pdfplus/10.1021/bc5001388
U2 - 10.1021/bc5001388
DO - 10.1021/bc5001388
M3 - Article
SN - 1043-1802
VL - 25
SP - 1011
EP - 1022
JO - Bioconjugate Chemistry
JF - Bioconjugate Chemistry
IS - 5
ER -