EGF receptor-targeting peptide conjugate incorporating a near-IR fluorescent dye and a novel 1,4,7-triazacyclononane-based 64Cu(II) chelator assembled via click chemistry

Katrin Viehweger; Lisa Barbaro; Karina Pombo-Garcia; Tanmaya Joshi; Gerhard Geipel; Jorg Steinbach; Holger Stephan; Leone Spiccia; Bimbil Graham

doi:10.1021/bc5001388

EGF receptor-targeting peptide conjugate incorporating a near-IR fluorescent dye and a novel 1,4,7-triazacyclononane-based 64Cu(II) chelator assembled via click chemistry

Katrin Viehweger, Lisa Barbaro, Karina Pombo-Garcia, Tanmaya Joshi, Gerhard Geipel, Jorg Steinbach, Holger Stephan, Leone Spiccia, Bimbil Graham

Research output: Contribution to journal › Article › Research › peer-review

20 Citations (Scopus)

Abstract

A new Boc-protected 1,4,7-triazacyclononane (TACN)-based pro-chelator compound featuring a clickable azidomethylpyridine pendant has been developed as a building block for the construction of multimodal imaging agents. Conjugation to a model alkyne (propargyl alcohol), followed by deprotection, generates a pentadentate ligand, as confirmed by X-ray crystallographic analysis of the corresponding distorted square-pyramidal Cu(II) complex. The ligand exhibits rapid 64Cu(II)-binding kinetics (>95 radiochemical yield in

Original language	English
Pages (from-to)	1011 - 1022
Number of pages	12
Journal	Bioconjugate Chemistry
Volume	25
Issue number	5
DOIs	https://doi.org/10.1021/bc5001388
Publication status	Published - 2014

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10.1021/bc5001388

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Viehweger, K., Barbaro, L., Pombo-Garcia, K., Joshi, T., Geipel, G., Steinbach, J., Stephan, H., Spiccia, L., & Graham, B. (2014). EGF receptor-targeting peptide conjugate incorporating a near-IR fluorescent dye and a novel 1,4,7-triazacyclononane-based 64Cu(II) chelator assembled via click chemistry. Bioconjugate Chemistry, 25(5), 1011 - 1022. https://doi.org/10.1021/bc5001388

Viehweger, Katrin ; Barbaro, Lisa ; Pombo-Garcia, Karina ; Joshi, Tanmaya ; Geipel, Gerhard ; Steinbach, Jorg ; Stephan, Holger ; Spiccia, Leone ; Graham, Bimbil. / EGF receptor-targeting peptide conjugate incorporating a near-IR fluorescent dye and a novel 1,4,7-triazacyclononane-based 64Cu(II) chelator assembled via click chemistry. In: Bioconjugate Chemistry. 2014 ; Vol. 25, No. 5. pp. 1011 - 1022.

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abstract = "A new Boc-protected 1,4,7-triazacyclononane (TACN)-based pro-chelator compound featuring a clickable azidomethylpyridine pendant has been developed as a building block for the construction of multimodal imaging agents. Conjugation to a model alkyne (propargyl alcohol), followed by deprotection, generates a pentadentate ligand, as confirmed by X-ray crystallographic analysis of the corresponding distorted square-pyramidal Cu(II) complex. The ligand exhibits rapid 64Cu(II)-binding kinetics (>95 radiochemical yield in",

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Viehweger, K, Barbaro, L, Pombo-Garcia, K, Joshi, T, Geipel, G, Steinbach, J, Stephan, H, Spiccia, L & Graham, B 2014, 'EGF receptor-targeting peptide conjugate incorporating a near-IR fluorescent dye and a novel 1,4,7-triazacyclononane-based 64Cu(II) chelator assembled via click chemistry', Bioconjugate Chemistry, vol. 25, no. 5, pp. 1011 - 1022. https://doi.org/10.1021/bc5001388

EGF receptor-targeting peptide conjugate incorporating a near-IR fluorescent dye and a novel 1,4,7-triazacyclononane-based 64Cu(II) chelator assembled via click chemistry. / Viehweger, Katrin; Barbaro, Lisa; Pombo-Garcia, Karina; Joshi, Tanmaya; Geipel, Gerhard; Steinbach, Jorg; Stephan, Holger; Spiccia, Leone; Graham, Bimbil.

In: Bioconjugate Chemistry, Vol. 25, No. 5, 2014, p. 1011 - 1022.

Research output: Contribution to journal › Article › Research › peer-review

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AU - Pombo-Garcia, Karina

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AU - Spiccia, Leone

AU - Graham, Bimbil

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