Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1011 - 1022 |
| Number of pages | 12 |
| Journal | Bioconjugate Chemistry |
| Volume | 25 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2014 |
Cite this
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EGF receptor-targeting peptide conjugate incorporating a near-IR fluorescent dye and a novel 1,4,7-triazacyclononane-based 64Cu(II) chelator assembled via click chemistry. / Viehweger, Katrin; Barbaro, Lisa; Pombo-Garcia, Karina; Joshi, Tanmaya; Geipel, Gerhard; Steinbach, Jorg; Stephan, Holger; Spiccia, Leone; Graham, Bimbil.
In: Bioconjugate Chemistry, Vol. 25, No. 5, 2014, p. 1011 - 1022.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - EGF receptor-targeting peptide conjugate incorporating a near-IR fluorescent dye and a novel 1,4,7-triazacyclononane-based 64Cu(II) chelator assembled via click chemistry
AU - Viehweger, Katrin
AU - Barbaro, Lisa
AU - Pombo-Garcia, Karina
AU - Joshi, Tanmaya
AU - Geipel, Gerhard
AU - Steinbach, Jorg
AU - Stephan, Holger
AU - Spiccia, Leone
AU - Graham, Bimbil
PY - 2014
Y1 - 2014
N2 - A new Boc-protected 1,4,7-triazacyclononane (TACN)-based pro-chelator compound featuring a clickable azidomethylpyridine pendant has been developed as a building block for the construction of multimodal imaging agents. Conjugation to a model alkyne (propargyl alcohol), followed by deprotection, generates a pentadentate ligand, as confirmed by X-ray crystallographic analysis of the corresponding distorted square-pyramidal Cu(II) complex. The ligand exhibits rapid 64Cu(II)-binding kinetics (>95 radiochemical yield in
AB - A new Boc-protected 1,4,7-triazacyclononane (TACN)-based pro-chelator compound featuring a clickable azidomethylpyridine pendant has been developed as a building block for the construction of multimodal imaging agents. Conjugation to a model alkyne (propargyl alcohol), followed by deprotection, generates a pentadentate ligand, as confirmed by X-ray crystallographic analysis of the corresponding distorted square-pyramidal Cu(II) complex. The ligand exhibits rapid 64Cu(II)-binding kinetics (>95 radiochemical yield in
UR - http://pubs.acs.org/doi/pdfplus/10.1021/bc5001388
U2 - 10.1021/bc5001388
DO - 10.1021/bc5001388
M3 - Article
VL - 25
SP - 1011
EP - 1022
JO - Bioconjugate Chemistry
JF - Bioconjugate Chemistry
SN - 1043-1802
IS - 5
ER -