Efficient T2 mapping with blip-up/down EPI and gSlider-SMS (T2-BUDA-gSlider)

Xiaozhi Cao, Kang Wang, Congyu Liao, Zijing Zhang, Siddharth Srinivasan Iyer, Zhifeng Chen, Wei Ching Lo, Huafeng Liu, Hongjian He, Kawin Setsompop, Jianhui Zhong, Berkin Bilgic

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13 Citations (Scopus)


Purpose: To rapidly obtain high isotropic-resolution T2 maps with whole-brain coverage and high geometric fidelity. Methods: A T2 blip-up/down EPI acquisition with generalized slice-dithered enhanced resolution (T2-BUDA-gSlider) is proposed. A RF-encoded multi-slab spin-echo (SE) EPI acquisition with multiple TEs was developed to obtain high SNR efficiency with reduced TR. This was combined with an interleaved 2-shot EPI acquisition using blip-up/down phase encoding. An estimated field map was incorporated into the joint multi-shot EPI reconstruction with a structured low rank constraint to achieve distortion-free and robust reconstruction for each slab without navigation. A Bloch simulated subspace model was integrated into gSlider reconstruction and used for T2 quantification. Results: In vivo results demonstrated that the T2 values estimated by the proposed method were consistent with gold standard spin-echo acquisition. Compared to the reference 3D fast spin echo (FSE) images, distortion caused by off-resonance and eddy current effects were effectively mitigated. Conclusion: BUDA-gSlider SE-EPI acquisition and gSlider-subspace joint reconstruction enabled distortion-free whole-brain T2 mapping in 2 min at ~1 mm3 isotropic resolution, which could bring significant benefits to related clinical and neuroscience applications.

Original languageEnglish
Pages (from-to)2064-2075
Number of pages12
JournalMagnetic Resonance in Medicine
Issue number4
Publication statusPublished - Oct 2021
Externally publishedYes


  • BUDA
  • gSlider
  • structured low rank
  • T map

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