Abstract
The heterogeneous solid acid catalysts Amberlyst-15 and silica-HClO 4 displays efficient catalytic properties for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones from anthranilamide and various aldehydes/ketones under mild reaction conditions and in good yields. These catalysts also showed good catalytic activity for condensation of anthranilamide with a cyclic enol ether 3,4-dihydropyran and led to formation of new unexpected quinazolinone product 6 comprising two dihydropyran moieties. The new product 6 has been reported for the first time and is fully characterized using 2D-NMR data. Furthermore, both solid acid catalysts can be easily recycled without significant loss of activity.
Original language | English |
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Pages (from-to) | 308-318 |
Number of pages | 11 |
Journal | ARKIVOC |
Volume | 2012 |
Issue number | 8 |
DOIs | |
Publication status | Published - 26 Aug 2012 |
Externally published | Yes |
Keywords
- 2,3-dihydroquinazolin-4(1H)-ones
- 3,4-dihydropyran
- Aldehydes
- Amberlyst-15
- Heterogeneous catalysis
- Ketones