Efficient co-delivery of a Pt(iv) prodrug and a p53 activator to enhance the anticancer activity of cisplatin

Rong Ma, Yiping Wang, Li Yan, Lili Ma, Zhigang Wang, Hoi Ching Chan, Sung Kay Chiu, Xianfeng Chen, Guangyu Zhu

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20 Citations (Scopus)

Abstract

A nanoplatform targeting DNA and p53 simultaneously is assembled. Layered double hydroxide nanoparticles are co-loaded with a Pt(iv) prodrug and a p53 activator. Once inside cells, cisplatin is released to attack genomic DNA and kill cancer cells; simultaneously, the p53 activator results in active p53, a key protein involved in the apoptotic pathways initiated by platinum drugs. The anticancer efficacy of cisplatin is significantly improved through this synergistic application.

Original languageEnglish
Pages (from-to)7859-7862
Number of pages4
JournalChemical Communications
Volume51
Issue number37
DOIs
Publication statusPublished - 7 May 2015
Externally publishedYes

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