Efficient chemoselective alkylation of quinoline 2,4-diol derivatives in water

Nafees Ahmed; Keyur G. Brahmbhatt; Inder P. Singh; Kamlesh K. Bhutani

doi:10.1002/jhet.364

Efficient chemoselective alkylation of quinoline 2,4-diol derivatives in water

Nafees Ahmed, Keyur G. Brahmbhatt, Inder P. Singh, Kamlesh K. Bhutani

Research output: Contribution to journal › Article › Research › peer-review

16 Citations (Scopus)

Abstract

Synthesis of various C-3-dialkyl derivatives of quinoline 2,4-diol was achieved by condensation of aniline or substituted anilines with diethyl malonate, followed by chemoselective alkylation at C-3 in water. The higher yields, easy work up and environmental compatible conditions are the main aspects of our method.

Original language	English
Pages (from-to)	237-240
Number of pages	4
Journal	Journal of Heterocyclic Chemistry
Volume	48
Issue number	1
DOIs	https://doi.org/10.1002/jhet.364
Publication status	Published - Jan 2011
Externally published	Yes

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title = "Efficient chemoselective alkylation of quinoline 2,4-diol derivatives in water",

abstract = "Synthesis of various C-3-dialkyl derivatives of quinoline 2,4-diol was achieved by condensation of aniline or substituted anilines with diethyl malonate, followed by chemoselective alkylation at C-3 in water. The higher yields, easy work up and environmental compatible conditions are the main aspects of our method.",

author = "Nafees Ahmed and Brahmbhatt, \{Keyur G.\} and Singh, \{Inder P.\} and Bhutani, \{Kamlesh K.\}",

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AU - Brahmbhatt, Keyur G.

AU - Singh, Inder P.

AU - Bhutani, Kamlesh K.

PY - 2011/1

Y1 - 2011/1

N2 - Synthesis of various C-3-dialkyl derivatives of quinoline 2,4-diol was achieved by condensation of aniline or substituted anilines with diethyl malonate, followed by chemoselective alkylation at C-3 in water. The higher yields, easy work up and environmental compatible conditions are the main aspects of our method.

AB - Synthesis of various C-3-dialkyl derivatives of quinoline 2,4-diol was achieved by condensation of aniline or substituted anilines with diethyl malonate, followed by chemoselective alkylation at C-3 in water. The higher yields, easy work up and environmental compatible conditions are the main aspects of our method.

UR - https://www.scopus.com/pages/publications/77954929510

U2 - 10.1002/jhet.364

DO - 10.1002/jhet.364

M3 - Article

AN - SCOPUS:77954929510

SN - 0022-152X

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SP - 237

EP - 240

JO - Journal of Heterocyclic Chemistry

JF - Journal of Heterocyclic Chemistry

IS - 1

ER -

Efficient chemoselective alkylation of quinoline 2,4-diol derivatives in water

Abstract

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