Efficient chemoselective alkylation of quinoline 2,4-diol derivatives in water

Nafees Ahmed, Keyur G. Brahmbhatt, Inder P. Singh, Kamlesh K. Bhutani

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13 Citations (Scopus)


Synthesis of various C-3-dialkyl derivatives of quinoline 2,4-diol was achieved by condensation of aniline or substituted anilines with diethyl malonate, followed by chemoselective alkylation at C-3 in water. The higher yields, easy work up and environmental compatible conditions are the main aspects of our method.

Original languageEnglish
Pages (from-to)237-240
Number of pages4
JournalJournal of Heterocyclic Chemistry
Issue number1
Publication statusPublished - Jan 2011
Externally publishedYes

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