Efficacy of systemically administered polymyxins in mouse burn wound infection caused by multidrug-resistant Gram-negative pathogens: A proof-of-concept study

Yu-Wei Lin, Ke Chen, Jiping Wang, Tony Velkov, Qi Zhou, Jian Li

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Abstract

The efficacy of subcutaneously administered polymyxins against burn wound infections caused by Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae was examined in a murine infection model. Subcutaneously administered colistin and polymyxin B achieved a >2-log10 reduction in the bacterial load for P. aeruginosa and A. baumannii infections, while wound infections by K. pneumoniae were less responsive (<1-log10 reduction). This study highlights the potential therapeutic benefits of parenteral polymyxins for treating burn wound infections.
Original languageEnglish
Article numbere02527-17
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume62
Issue number5
DOIs
Publication statusPublished - May 2018

Keywords

  • polymyxins
  • thermal injury
  • multidrug-resistant
  • Pseudomonas aeruginosa
  • Acinetobacter baumannii
  • Klebsiella pneumoniae

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