Efficacy of ion-exchange resins for anti-tumour drug delivery

M. A. Burton, C. Jones, J. M. Trotter, B. N. Gray, J. P. Codde

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Abstract

The comparative efficacy of chemotherapy delivered on ion-exchange microspheres or as a conventional free drug preparation was measured in an implanted rat tumour model. The drugs Adriamycin and mitoxantrone were combined with resin microspheres and embolised in the vasculature of the hind limb and implanted tumour. The growth rate of the tumours was measured serially in each animal before and after treatment and compared with that of untreated control animals. A comparison was also made between the growth rate of tumours in animals treated with similar numbers of microspheres without any drug. Both drugs were shown to decrease tumour growth rate significantly when introduced in the free form, but mitoxantrone-treated rats did not survive this treatment as long as the control animals. However, when the drugs were administered on microspheres the growth rate was again significantly reduced against controls and no animals died prematurely in either drug group. There was a significant enhanced response in the Adriamycin-microsphere-treated group compared to the free-drug group. Microspheres alone were shown to have no effect on tumour growth when administered in the same numbers as those used in the drug-microsphere groups. The use of ion-exchange resin microspheres was shown to be beneficial both in terms of an enhanced absolute response and in terms of reducing the whole-body toxic effects of the drugs.

Original languageEnglish
Pages (from-to)36-39
Number of pages4
JournalRegional Cancer Treatment
Volume3
Issue number1
Publication statusPublished - 1 Jan 1990
Externally publishedYes

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