TY - JOUR
T1 - Efficacy and safety of topical Trikatu preparation in, relieving mosquito bite reactions: a randomized controlled trial
AU - Maenthaisong, Ratree
AU - Chaiyakunapruk, Nathorn
AU - Tiyaboonchai, Waree
AU - Tawatsin, Apiwat
AU - Rojanawiwat, Archawin
AU - Thavara, Usavadee
PY - 2014
Y1 - 2014
N2 - Introduction: Trikatu is composed of dried fruits of Piper nigrum L and Piper retrofractum Vahl, and dried rhizomes of Zingiber officinale R. Although this preparation has been used to relieve pruritis, pain, and inflammation for a long time, there is no clinical evidence to confirm its efficacy and safety. Therefore, we performed a double-blind, within person-randomized controlled study of 30 healthy volunteers to determine efficacy and safety of topical Trikatu on mosquito bite reactions. Methods: All subjects were bitten by Aedes aegypti laboratory mosquitoes on their forearms and they were randomly assigned arms to apply either Trikatu or reference product on the mosquito bite papule. The main outcome was the difference of papule size reduction at 30. min, measured by a caliper, between the Trikatu and reference arms. Pruritis, redness, pain, and patient satisfaction were assessed at 15, 30, 60, 180, and 360. min as secondary outcomes. Results: There were no significant differences between treatment and reference arms on any outcome at any time of measurement. Conclusion: Trikatu did not show additional effects for relieving mosquito bite reaction as compared with the reference product containing camphor, menthol, and eucalyptus. For further study, it is very important to consider a proper selection of subjects, comparator product, and concentration of extract when Trikatu preparation is investigated.
AB - Introduction: Trikatu is composed of dried fruits of Piper nigrum L and Piper retrofractum Vahl, and dried rhizomes of Zingiber officinale R. Although this preparation has been used to relieve pruritis, pain, and inflammation for a long time, there is no clinical evidence to confirm its efficacy and safety. Therefore, we performed a double-blind, within person-randomized controlled study of 30 healthy volunteers to determine efficacy and safety of topical Trikatu on mosquito bite reactions. Methods: All subjects were bitten by Aedes aegypti laboratory mosquitoes on their forearms and they were randomly assigned arms to apply either Trikatu or reference product on the mosquito bite papule. The main outcome was the difference of papule size reduction at 30. min, measured by a caliper, between the Trikatu and reference arms. Pruritis, redness, pain, and patient satisfaction were assessed at 15, 30, 60, 180, and 360. min as secondary outcomes. Results: There were no significant differences between treatment and reference arms on any outcome at any time of measurement. Conclusion: Trikatu did not show additional effects for relieving mosquito bite reaction as compared with the reference product containing camphor, menthol, and eucalyptus. For further study, it is very important to consider a proper selection of subjects, comparator product, and concentration of extract when Trikatu preparation is investigated.
UR - http://www.sciencedirect.com/science/article/pii/S0965229913001362
U2 - 10.1016/j.ctim.2013.08.014
DO - 10.1016/j.ctim.2013.08.014
M3 - Article
VL - 22
SP - 34
EP - 39
JO - Complementary Therapies in Medicine
JF - Complementary Therapies in Medicine
SN - 0965-2299
IS - 1
ER -