Efficacy and safety of levetiracetam as adjunctive therapy in adult patients with uncontrolled partial epilepsy: The Asia SKATE II Study

Patrick Kwan, Shih Hui Lim, Yotin Chinvarun, Leonor Cabral-Lim, Zariah Abdul Aziz, Yuk Keung Lo, Françoise Tonner, Kevin Beh, Pascal Edrich

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This study evaluated the safety and efficacy of levetiracetam as adjunctive therapy for partial seizures in everyday clinical practice in Asian populations. Patients aged ≥16. years (N=251) with inadequately controlled partial epilepsy were recruited from 29 centers across Asia. Levetiracetam was added to existing antiepileptic medication for 16. weeks at a starting dose of 500 or 1000. mg/day and titrated to a maximum of 3000. mg/day according to clinical response. The study completion rate was 86.9%. Adverse events were reported by 73.3% of patients and were generally mild, leading to treatment withdrawal in only 7.2%. The most common adverse events were somnolence (30.3%) and dizziness (14.7%). Compared with pretreatment baseline, 44.0% of patients had a ≥50% reduction in seizure frequency, with a median reduction of 46.4%, and 17.7% became seizure free during the treatment period. Levetiracetam was well tolerated and efficacious as adjunctive therapy for partial epilepsy in clinical practice among Asian populations.

Original languageEnglish
Pages (from-to)100-105
Number of pages6
JournalEpilepsy and Behavior
Issue number1-2
Publication statusPublished - 1 May 2010
Externally publishedYes


  • Adjunctive therapy
  • Asian patients
  • Epilepsy
  • Levetiracetam
  • Partial seizures

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