Efficacy and adverse effects of topical chloramphenicol ointment use for surgical wounds: A systematic review

Amanda Y. Shen, Elie J. Haddad, David J. Hunter-Smith, Warren M. Rozen

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Background: Chloramphenicol ointment is often used in plastic and dermatologic surgery as a topical antibiotic for surgical wounds, but evidence regarding its efficacy and side effects is lacking. In addition, anecdotal fear of aplastic anaemia exists from the oral use of this drug. We performed a systematic review of the literature to assess the efficacy and side effect profile of topical chloramphenicol ointment on non-ocular surgical wounds. Methods: A systematic search of MEDLINE, EMBASE and the Cochrane Library from inception until 4 September 2017 was undertaken. Clinical studies of topical chloramphenicol ointment use on surgical wounds were included. Studies looking only at ocular use or those not available in full text or English were excluded. The review was conducted adhering to PRISMA guidelines. Results: After full-text review, five articles were included. Two were randomized controlled trials, one was retrospective case control and two were case studies. There was evidence that chloramphenicol ointment use on surgical wounds produced a non-statistically significant reduction in infection rates. Delayed hypersensitivity and acute oesophagitis were noted as potential side effects of non-ocular topical use. Aplastic anaemia was not reported. Conclusion: There is a paucity of clinical data regarding the use of topical chloramphenicol ointment on surgical wounds. Further randomized controlled trials may be beneficial in order to support or refute its use in this setting.

Original languageEnglish
Pages (from-to)1243-1246
Number of pages4
JournalANZ Journal of Surgery
Volume88
Issue number12
DOIs
Publication statusPublished - 1 Dec 2018

Keywords

  • Chloramphenicol
  • Chloromycetin
  • Dermatologic
  • Dressings
  • Side effect
  • Topical
  • Wound

Cite this

@article{4d4a20aee4d140498251f60a3628546e,
title = "Efficacy and adverse effects of topical chloramphenicol ointment use for surgical wounds: A systematic review",
abstract = "Background: Chloramphenicol ointment is often used in plastic and dermatologic surgery as a topical antibiotic for surgical wounds, but evidence regarding its efficacy and side effects is lacking. In addition, anecdotal fear of aplastic anaemia exists from the oral use of this drug. We performed a systematic review of the literature to assess the efficacy and side effect profile of topical chloramphenicol ointment on non-ocular surgical wounds. Methods: A systematic search of MEDLINE, EMBASE and the Cochrane Library from inception until 4 September 2017 was undertaken. Clinical studies of topical chloramphenicol ointment use on surgical wounds were included. Studies looking only at ocular use or those not available in full text or English were excluded. The review was conducted adhering to PRISMA guidelines. Results: After full-text review, five articles were included. Two were randomized controlled trials, one was retrospective case control and two were case studies. There was evidence that chloramphenicol ointment use on surgical wounds produced a non-statistically significant reduction in infection rates. Delayed hypersensitivity and acute oesophagitis were noted as potential side effects of non-ocular topical use. Aplastic anaemia was not reported. Conclusion: There is a paucity of clinical data regarding the use of topical chloramphenicol ointment on surgical wounds. Further randomized controlled trials may be beneficial in order to support or refute its use in this setting.",
keywords = "Chloramphenicol, Chloromycetin, Dermatologic, Dressings, Side effect, Topical, Wound",
author = "Shen, {Amanda Y.} and Haddad, {Elie J.} and Hunter-Smith, {David J.} and Rozen, {Warren M.}",
year = "2018",
month = "12",
day = "1",
doi = "10.1111/ans.14465",
language = "English",
volume = "88",
pages = "1243--1246",
journal = "ANZ Journal of Surgery",
issn = "1445-1433",
publisher = "Wiley-Blackwell",
number = "12",

}

Efficacy and adverse effects of topical chloramphenicol ointment use for surgical wounds : A systematic review. / Shen, Amanda Y.; Haddad, Elie J.; Hunter-Smith, David J.; Rozen, Warren M.

In: ANZ Journal of Surgery, Vol. 88, No. 12, 01.12.2018, p. 1243-1246.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - Efficacy and adverse effects of topical chloramphenicol ointment use for surgical wounds

T2 - A systematic review

AU - Shen, Amanda Y.

AU - Haddad, Elie J.

AU - Hunter-Smith, David J.

AU - Rozen, Warren M.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Background: Chloramphenicol ointment is often used in plastic and dermatologic surgery as a topical antibiotic for surgical wounds, but evidence regarding its efficacy and side effects is lacking. In addition, anecdotal fear of aplastic anaemia exists from the oral use of this drug. We performed a systematic review of the literature to assess the efficacy and side effect profile of topical chloramphenicol ointment on non-ocular surgical wounds. Methods: A systematic search of MEDLINE, EMBASE and the Cochrane Library from inception until 4 September 2017 was undertaken. Clinical studies of topical chloramphenicol ointment use on surgical wounds were included. Studies looking only at ocular use or those not available in full text or English were excluded. The review was conducted adhering to PRISMA guidelines. Results: After full-text review, five articles were included. Two were randomized controlled trials, one was retrospective case control and two were case studies. There was evidence that chloramphenicol ointment use on surgical wounds produced a non-statistically significant reduction in infection rates. Delayed hypersensitivity and acute oesophagitis were noted as potential side effects of non-ocular topical use. Aplastic anaemia was not reported. Conclusion: There is a paucity of clinical data regarding the use of topical chloramphenicol ointment on surgical wounds. Further randomized controlled trials may be beneficial in order to support or refute its use in this setting.

AB - Background: Chloramphenicol ointment is often used in plastic and dermatologic surgery as a topical antibiotic for surgical wounds, but evidence regarding its efficacy and side effects is lacking. In addition, anecdotal fear of aplastic anaemia exists from the oral use of this drug. We performed a systematic review of the literature to assess the efficacy and side effect profile of topical chloramphenicol ointment on non-ocular surgical wounds. Methods: A systematic search of MEDLINE, EMBASE and the Cochrane Library from inception until 4 September 2017 was undertaken. Clinical studies of topical chloramphenicol ointment use on surgical wounds were included. Studies looking only at ocular use or those not available in full text or English were excluded. The review was conducted adhering to PRISMA guidelines. Results: After full-text review, five articles were included. Two were randomized controlled trials, one was retrospective case control and two were case studies. There was evidence that chloramphenicol ointment use on surgical wounds produced a non-statistically significant reduction in infection rates. Delayed hypersensitivity and acute oesophagitis were noted as potential side effects of non-ocular topical use. Aplastic anaemia was not reported. Conclusion: There is a paucity of clinical data regarding the use of topical chloramphenicol ointment on surgical wounds. Further randomized controlled trials may be beneficial in order to support or refute its use in this setting.

KW - Chloramphenicol

KW - Chloromycetin

KW - Dermatologic

KW - Dressings

KW - Side effect

KW - Topical

KW - Wound

UR - http://www.scopus.com/inward/record.url?scp=85044303871&partnerID=8YFLogxK

U2 - 10.1111/ans.14465

DO - 10.1111/ans.14465

M3 - Review Article

VL - 88

SP - 1243

EP - 1246

JO - ANZ Journal of Surgery

JF - ANZ Journal of Surgery

SN - 1445-1433

IS - 12

ER -