Effects of yohimbine stereoisomers on contractions of rat aortic strips produced by agonists with different selectivity for α1-and α2-adrenoceptors

Kevin G. Digges, Roger J. Summers

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16 Citations (Scopus)

Abstract

Three stereoisomers of yohimbine (corynanthine, rauwolscine and yohimbine) have been used to characterize α-adrenoceptors in rat aortic strips. pA2 values for each antagonist were calculated using 3 different agonists ((-)-noradrenaline, (-)-phenylephrine and guanfacine) which possess varying affinities for α1 and α2 receptors. Mean pA2 values were not significantly different irrespective of the agonist used and the order of the potency was corynanthine > yohimbine > rauwolscine. The results are consistent with the presence of α1-adrenoceptors in rat aorta.

Original languageEnglish
Pages (from-to)95-99
Number of pages5
JournalEuropean Journal of Pharmacology
Volume96
Issue number1-2
DOIs
Publication statusPublished - 9 Dec 1983

Keywords

  • Corynanthine
  • Rat aorta
  • Rauwolscine
  • Yohimbine
  • α-Adrenoceptor

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