Effects of valproate or lamotrigine monotherapy on the reproductive endocrine and insulin-related metabolic profile in Chinese adults with epilepsy: A prospective randomized study

Patrick Kwan, Fung Ping Yip, Andrew C.F. Hui, Howan Leung, Ping Wing Ng, Kwok Fai Hui, Iris H.S. Chan, Michael H.M. Chan, Christopher W.K. Lam

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12 Citations (Scopus)


Cross-sectional studies have suggested that valproate treatment may be associated with hyperinsulinemia and hyperandrogenism in women. Few prospective data are available. We evaluated the reproductive endocrine and insulin-related metabolic parameters in men and women with untreated epilepsy randomized to valproate (n = 44) or lamotrigine (n = 37) monotherapy for 12 months. On treatment, there was no significant difference in fasting serum insulin concentrations between the two groups. In women (n = 40), there was no significant difference between the two groups in change from baseline in serum total testosterone, dehydroepiandrosterone sulfate, luteinizing hormone, or follicle-stimulating hormone. In men (n = 41), follicle-stimulating hormone concentration significantly decreased in patients taking valproate compared with those on lamotrigine as early as 3 months after treatment. Greater attention should be paid to investigate the potential impact of valproate on reproductive function in men.

Original languageEnglish
Pages (from-to)610-616
Number of pages7
JournalEpilepsy and Behavior
Issue number4
Publication statusPublished - 1 Apr 2009
Externally publishedYes


  • Antiepileptic drug
  • Dehydroepiandrosterone
  • Follicle-stimulating hormone
  • Glucose
  • Insulin
  • Lamotrigine
  • Lipids
  • Luteinizing hormone
  • Testosterone
  • Valproate

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