Effects of selective beta1-adrenoceptor blockade on cardiovascular and renal function and circulating cytokines in ovine hyperdynamic sepsis

Paolo Calzavacca, Yugeesh Ryan Lankadeva, Simon R Bailey, Michael John Bailey, Rinaldo Bellomo, Clive N May

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19 Citations (Scopus)

Abstract

Introduction: Activation of the sympathetic nervous system has beneficial cardiovascular effects in sepsis, but there is also evidence that sympatholytics have beneficial actions in sepsis. We therefore determined the effect of selective ?1-adrenoceptor blockade on cardiac and renal function and cytokine release in ovine hyperdynamic sepsis. Methods: Hyperdynamic sepsis was induced by infusion of live E. coli for 24 hours in nine conscious sheep instrumented with flow probes on the pulmonary and left renal artery. Cardiovascular and renal function and levels of plasma cytokines were determined in a control group and during selective ?1-adrenoceptor blockade with atenolol (10 mg intravenous bolus then 0.125 mg/kg/h) from 8 to 24 hours of sepsis. Results: Hyperdynamic sepsis was characterized by hypotension with increases in cardiac output (CO), heart rate (HR) and renal blood flow (RBF), and acute kidney injury. Atenolol caused sustained reductions in HR (P
Original languageEnglish
Pages (from-to)1 - 10
Number of pages10
JournalCritical Care
Volume18
Issue number6 (Art. No.: 610)
DOIs
Publication statusPublished - 2014

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