Abstract
Heterocyclic compounds such as quinazolinones have variety of biological and pharmacological properties (anticancer, antiinflammatory, antimicrobial, antimalaria, etc.). In this study, effects of a new quinazolinone, 4(3H) quinazolinone-2-ethyl-2-phenyl ethyl (QEPE), were investigated on the ovaries of Balb/C mice embryos. Pregnant Balb/C mice were divided into three groups of control, sham and experimental. Control mice remained intact, sham and experimental groups received 0.05% methyl cellulose and 100 mg/kg/body weight of QEPE, intraperitoneally (IP), on days 16.5th and 18.5th of gestation. Morphological observations showed abnormal embryos, underdeveloped embryos and severe hemorrhage in the neck region of QEPE treated embryos. Histological and pathological studies demonstrated that QEPE reduced the number and size of the oocytes of the embryonic ovaries. In conclusion the present results demonstrate QEPE is teratogenic and toxicogenic chemical, affecting internal organs such as ovaries at histological level.
| Original language | English |
|---|---|
| Pages (from-to) | 132-138 |
| Number of pages | 7 |
| Journal | Pharmacologyonline |
| Volume | 3 |
| Publication status | Published - 1 Dec 2012 |
| Externally published | Yes |
Keywords
- Embryonic ovary
- Oocyte number
- Oocyte size
- Quinazolinones