TY - JOUR
T1 - Effects of pulmonary rehabilitation in lung transplant candidates
T2 - A systematic review
AU - Hoffman, Mariana
AU - Chaves, Gabriela
AU - Ribeiro-Samora, Giane Amorim
AU - Britto, Raquel Rodrigues
AU - Parreira, Verônica Franco
N1 - Funding Information:
This project was partially supported by Pr?-Reitoria de Pesquisa da Universidade Federal de Minas Gerais and by Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (grant numbers: 309494/2013-3 and 442973/2014-4), Brazil.
PY - 2017/1
Y1 - 2017/1
N2 - Objectives: The aim of this systematic review of randomised controlled trials (RCTs), and quasiexperimental and retrospective studies is to investigate the effects of pulmonary rehabilitation (PR) in patients with advanced chronic disease on the waiting list for lung transplantation. Setting: PR performed for inpatient or outpatient lung transplant candidates. Intervention: PR programme including aerobic exercise training and/or resistance exercise training. Primary and secondary outcomes: Quality of life and exercise capacity (primary outcomes). Survival rate after transplant surgery; pulmonary function; respiratory muscle strength; psychological aspects; upper and lower extremity muscle strength and adverse effects (secondary outcomes). Two review authors independently selected the studies, assessed study quality and extracted data. Studies in any language were included. Results: This was a systematic review and studies were searched on the Cochrane Library, MEDLINE, EMBASE, CINAHL and PEDro. Experimental and retrospective studies evaluating the effects of PR in candidates for lung transplantation (>18 years old) with any lung diseases were included. 2 RCTs, and two quasi-experimental and two retrospectives studies, involving 1305 participants were included in the review. 5 studies included an enhancement reported in quality of life using the Short Form 36 questionnaire and showed improvements in some domains. All studies included exercise capacity evaluated through 6 min walk test and in five of them, there were improvements in this outcome after PR. Owing to the different characteristics of the studies, it was not possible to perform a meta-analysis. Conclusions: Studies included in this review showed that PR is an effective treatment option for patients on the waiting list for lung transplantation and can improve quality of life and exercise capacity in those patients. Although individual studies reported positive effects of PR, this review shows that there is a need for more studies of a high methodological quality addressing PR effects in lung transplant candidates.
AB - Objectives: The aim of this systematic review of randomised controlled trials (RCTs), and quasiexperimental and retrospective studies is to investigate the effects of pulmonary rehabilitation (PR) in patients with advanced chronic disease on the waiting list for lung transplantation. Setting: PR performed for inpatient or outpatient lung transplant candidates. Intervention: PR programme including aerobic exercise training and/or resistance exercise training. Primary and secondary outcomes: Quality of life and exercise capacity (primary outcomes). Survival rate after transplant surgery; pulmonary function; respiratory muscle strength; psychological aspects; upper and lower extremity muscle strength and adverse effects (secondary outcomes). Two review authors independently selected the studies, assessed study quality and extracted data. Studies in any language were included. Results: This was a systematic review and studies were searched on the Cochrane Library, MEDLINE, EMBASE, CINAHL and PEDro. Experimental and retrospective studies evaluating the effects of PR in candidates for lung transplantation (>18 years old) with any lung diseases were included. 2 RCTs, and two quasi-experimental and two retrospectives studies, involving 1305 participants were included in the review. 5 studies included an enhancement reported in quality of life using the Short Form 36 questionnaire and showed improvements in some domains. All studies included exercise capacity evaluated through 6 min walk test and in five of them, there were improvements in this outcome after PR. Owing to the different characteristics of the studies, it was not possible to perform a meta-analysis. Conclusions: Studies included in this review showed that PR is an effective treatment option for patients on the waiting list for lung transplantation and can improve quality of life and exercise capacity in those patients. Although individual studies reported positive effects of PR, this review shows that there is a need for more studies of a high methodological quality addressing PR effects in lung transplant candidates.
UR - http://www.scopus.com/inward/record.url?scp=85011596010&partnerID=8YFLogxK
U2 - 10.1136/bmjopen-2016-013445
DO - 10.1136/bmjopen-2016-013445
M3 - Article
C2 - 28159852
AN - SCOPUS:85011596010
SN - 2044-6055
VL - 7
JO - BMJ Open
JF - BMJ Open
IS - 2
M1 - e013445
ER -