TY - JOUR
T1 - Effects of probiotic yogurt consumption on metabolic factors in individuals with nonalcoholic fatty liver disease
AU - Nabavi, S.
AU - Rafraf, M.
AU - Somi, M. H.
AU - Homayouni-Rad, A.
AU - Asghari-Jafarabadi, M.
N1 - Funding Information:
We thank the Research Vice-Chancellor and Nutrition Research Center of Tabriz University of Medical Sciences (Tabriz, Iran) for the financial support; Pegah Dairy Industries Co. (Tabriz, Iran) for supplying the probiotic and conventional yogurts; and the patients who participated in this study.
Publisher Copyright:
© 2014 American Dairy Science Association.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - The aim of this study was to investigate the effects of probiotic yogurt consumption on some metabolic factors in nonalcoholic fatty liver disease (NAFLD) patients. This double-blind, randomized, controlled clinical trial was conducted on 72 patients with NAFLD (33 males and 39 females) aged 23 to 63 yr. Subjects in the intervention group (n. =. 36) consumed 300. g/d of probiotic yogurt containing Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 and those in the control group (n. =. 36) consumed 300. g/d of conventional yogurt for 8 wk. Fasting blood samples, anthropometric measurements, and dietary records (24. h/d for 3 d) were collected at baseline and at the end of the trial. Probiotic yogurt consumption resulted in reductions of 4.67, 5.42, 4.1, and 6.92% in serum levels of alanine aminotransferase, aspartate aminotransferase, total cholesterol, and low-density lipoprotein cholesterol, respectively, compared with control group. No significant changes were observed in levels of serum glucose, triglycerides, or high-density lipoprotein cholesterol in either group. Probiotic yogurt consumption improved hepatic enzymes, serum total cholesterol, and low-density lipoprotein cholesterol levels in studied subjects and might be useful in management of NAFLD risk factors.
AB - The aim of this study was to investigate the effects of probiotic yogurt consumption on some metabolic factors in nonalcoholic fatty liver disease (NAFLD) patients. This double-blind, randomized, controlled clinical trial was conducted on 72 patients with NAFLD (33 males and 39 females) aged 23 to 63 yr. Subjects in the intervention group (n. =. 36) consumed 300. g/d of probiotic yogurt containing Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 and those in the control group (n. =. 36) consumed 300. g/d of conventional yogurt for 8 wk. Fasting blood samples, anthropometric measurements, and dietary records (24. h/d for 3 d) were collected at baseline and at the end of the trial. Probiotic yogurt consumption resulted in reductions of 4.67, 5.42, 4.1, and 6.92% in serum levels of alanine aminotransferase, aspartate aminotransferase, total cholesterol, and low-density lipoprotein cholesterol, respectively, compared with control group. No significant changes were observed in levels of serum glucose, triglycerides, or high-density lipoprotein cholesterol in either group. Probiotic yogurt consumption improved hepatic enzymes, serum total cholesterol, and low-density lipoprotein cholesterol levels in studied subjects and might be useful in management of NAFLD risk factors.
KW - Metabolic factor
KW - Nonalcoholic fatty liver disease
KW - Probiotic yogurt
UR - http://www.scopus.com/inward/record.url?scp=84919326883&partnerID=8YFLogxK
U2 - 10.3168/jds.2014-8500
DO - 10.3168/jds.2014-8500
M3 - Article
C2 - 25306266
AN - SCOPUS:84919326883
SN - 0022-0302
VL - 97
SP - 7386
EP - 7393
JO - Journal of Dairy Science
JF - Journal of Dairy Science
IS - 12
ER -