Effects of prenatal ethanol exposure on the lungs of postnatal lambs

Foula Sozo; Melissa Vela; Victoria Stokes; Kelly Rebecca Kenna; Peter J Meikle; Robert M De Matteo; David William Walker; James F Brien; Alan D Bocking; Richard L Harding

doi:10.1152/ajplung.00195.2010

Effects of prenatal ethanol exposure on the lungs of postnatal lambs

Foula Sozo, Melissa Vela, Victoria Stokes, Kelly Rebecca Kenna, Peter J Meikle, Robert M De Matteo, David William Walker, James F Brien, Alan D Bocking, Richard L Harding

Research output: Contribution to journal › Article › Research › peer-review

21 Citations (Scopus)

Abstract

Prenatal ethanol exposure increases collagen deposition and alters surfactant protein (SP) expression and immune status in the lungs of near-term fetal sheep. Our objectives were to determine (a) if these prenatal effects of repeated gestational ethanol exposure persist after birth, and (b) whether surfactant phospholipid composition is altered following prenatal ethanol exposure. Pregnant ewes were chronically catheterized at 90 days of gestational age (DGA) and given a 1h daily infusion of either 0.75g ethanol/kg (n=9) or saline (n=7) from 95-135 DGA; ethanol administration ceased after 135 DGA. Lambs were born naturally at term (146+/-0.5 DGA). Lung tissue was examined at 9 weeks postnatal age for alterations in structure, SP expression and inflammation; bronchoalveolar lavage fluid (BALF) was examined for alterations in surfactant phospholipid composition. At 134 DGA, surfactant phospholipid concentration in amniotic fluid was significantly reduced (p

Original language	English
Pages (from-to)	L139 - L147
Number of pages	9
Journal	American Journal of Physiology - Lung Cellular and Molecular Physiology
Volume	300
Issue number	1
DOIs	https://doi.org/10.1152/ajplung.00195.2010
Publication status	Published - 2011

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title = "Effects of prenatal ethanol exposure on the lungs of postnatal lambs",

abstract = "Prenatal ethanol exposure increases collagen deposition and alters surfactant protein (SP) expression and immune status in the lungs of near-term fetal sheep. Our objectives were to determine (a) if these prenatal effects of repeated gestational ethanol exposure persist after birth, and (b) whether surfactant phospholipid composition is altered following prenatal ethanol exposure. Pregnant ewes were chronically catheterized at 90 days of gestational age (DGA) and given a 1h daily infusion of either 0.75g ethanol/kg (n=9) or saline (n=7) from 95-135 DGA; ethanol administration ceased after 135 DGA. Lambs were born naturally at term (146+/-0.5 DGA). Lung tissue was examined at 9 weeks postnatal age for alterations in structure, SP expression and inflammation; bronchoalveolar lavage fluid (BALF) was examined for alterations in surfactant phospholipid composition. At 134 DGA, surfactant phospholipid concentration in amniotic fluid was significantly reduced (p",

author = "Foula Sozo and Melissa Vela and Victoria Stokes and Kenna, {Kelly Rebecca} and Meikle, {Peter J} and {De Matteo}, {Robert M} and Walker, {David William} and Brien, {James F} and Bocking, {Alan D} and Harding, {Richard L}",

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AU - Sozo, Foula

AU - Vela, Melissa

AU - Stokes, Victoria

AU - Kenna, Kelly Rebecca

AU - Meikle, Peter J

AU - De Matteo, Robert M

AU - Walker, David William

AU - Brien, James F

AU - Bocking, Alan D

AU - Harding, Richard L

PY - 2011

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Effects of prenatal ethanol exposure on the lungs of postnatal lambs

Abstract

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