Effects of prenatal ethanol exposure on the lungs of postnatal lambs

Foula Sozo, Melissa Vela, Victoria Stokes, Kelly Rebecca Kenna, Peter J Meikle, Robert M De Matteo, David William Walker, James F Brien, Alan D Bocking, Richard L Harding

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Abstract

Prenatal ethanol exposure increases collagen deposition and alters surfactant protein (SP) expression and immune status in the lungs of near-term fetal sheep. Our objectives were to determine (a) if these prenatal effects of repeated gestational ethanol exposure persist after birth, and (b) whether surfactant phospholipid composition is altered following prenatal ethanol exposure. Pregnant ewes were chronically catheterized at 90 days of gestational age (DGA) and given a 1h daily infusion of either 0.75g ethanol/kg (n=9) or saline (n=7) from 95-135 DGA; ethanol administration ceased after 135 DGA. Lambs were born naturally at term (146+/-0.5 DGA). Lung tissue was examined at 9 weeks postnatal age for alterations in structure, SP expression and inflammation; bronchoalveolar lavage fluid (BALF) was examined for alterations in surfactant phospholipid composition. At 134 DGA, surfactant phospholipid concentration in amniotic fluid was significantly reduced (p
Original languageEnglish
Pages (from-to)L139 - L147
Number of pages9
JournalAmerican Journal of Physiology - Lung Cellular and Molecular Physiology
Volume300
Issue number1
DOIs
Publication statusPublished - 2011

Cite this