TY - JOUR
T1 - Effects of physical training during pregnancy on body weight gain, blood glucose and cholesterol in adult rats submitted to perinatal undernutrition
AU - Falcão-Tebas, Filippe
AU - Tobias, Amanda Thereza
AU - Bento-Santos, Adriano
AU - dos Santos, José Antônio
AU - de Vasconcelos, Diogo Antônio Alves
AU - Fidalgo, Marco Antônio
AU - Manhães-de-Castro, Raul
AU - Leandro, Carol Góis
PY - 2012/1
Y1 - 2012/1
N2 - The incompatibility of perinatal undernutrition and adequate nutrition during development increases the risk of early onset of non-communicable diseases in adulthood. However, it has been considered that maternal physical activity may attenuate these effects. This study aimed to evaluate the effects of physical training during pregnancy on body weight gain, waist circumference, glycaemia and cholesterolemia in adult offspring submitted to perinatal undernutrition. Female Wistar rats (n = 12) were divided into four groups: Control (C, n = 3), trained (T, n = 3), undernourished (U, n = 3) undernourished and trained (T+U, n = 3). During gestation and lactation, U and T+U groups were fed a low protein diet (8% casein) and C and T groups fed a normal protein diet (17% casein). The protocol of moderate physical training was performed on a treadmill (5 days/week, 60 min/day, at 65% of VO2max) and began 4 weeks before pregnancy. At pregnancy, the duration and intensity of training were reduced (5 days/week, 20 min/day, at 30% VO2max) until the 19th prenatal day. At weaning, male pups (CP = 9, TP = 9, UP = 7, T+UP = 9) received standard diet and evaluations took place at 270 days old. Abdominal circumference (AC) was evaluated in relation to body weight. Enzymatic colorimetric method glucose-oxidase/peroxidase and cholesterol-oxidase was used to evaluate fasting glycaemia and cholesterolemia, respectively. Rats from UP group showed high body weight gain during growth, higher AC, glycaemia and cholesterolemia values when compared to CP. Concerning the T+UP group, body weight gain was attenuated, and the AC, glycaemia and cholesterolemia were normalized (p<0.05). These results demonstrate that physical training during pregnancy reduces the effects of perinatal undernutrition on some murinometric and biochemical indicators of adult offspring.
AB - The incompatibility of perinatal undernutrition and adequate nutrition during development increases the risk of early onset of non-communicable diseases in adulthood. However, it has been considered that maternal physical activity may attenuate these effects. This study aimed to evaluate the effects of physical training during pregnancy on body weight gain, waist circumference, glycaemia and cholesterolemia in adult offspring submitted to perinatal undernutrition. Female Wistar rats (n = 12) were divided into four groups: Control (C, n = 3), trained (T, n = 3), undernourished (U, n = 3) undernourished and trained (T+U, n = 3). During gestation and lactation, U and T+U groups were fed a low protein diet (8% casein) and C and T groups fed a normal protein diet (17% casein). The protocol of moderate physical training was performed on a treadmill (5 days/week, 60 min/day, at 65% of VO2max) and began 4 weeks before pregnancy. At pregnancy, the duration and intensity of training were reduced (5 days/week, 20 min/day, at 30% VO2max) until the 19th prenatal day. At weaning, male pups (CP = 9, TP = 9, UP = 7, T+UP = 9) received standard diet and evaluations took place at 270 days old. Abdominal circumference (AC) was evaluated in relation to body weight. Enzymatic colorimetric method glucose-oxidase/peroxidase and cholesterol-oxidase was used to evaluate fasting glycaemia and cholesterolemia, respectively. Rats from UP group showed high body weight gain during growth, higher AC, glycaemia and cholesterolemia values when compared to CP. Concerning the T+UP group, body weight gain was attenuated, and the AC, glycaemia and cholesterolemia were normalized (p<0.05). These results demonstrate that physical training during pregnancy reduces the effects of perinatal undernutrition on some murinometric and biochemical indicators of adult offspring.
KW - Low-protein diet
KW - Phenotypic plasticity
KW - Physical exercise
UR - http://www.scopus.com/inward/record.url?scp=84861644650&partnerID=8YFLogxK
U2 - 10.1590/S1517-86922012000100012
DO - 10.1590/S1517-86922012000100012
M3 - Article
AN - SCOPUS:84861644650
SN - 1517-8692
VL - 18
SP - 58
EP - 62
JO - Revista Brasileira de Medicina do Esporte
JF - Revista Brasileira de Medicina do Esporte
IS - 1
ER -