Effects of molybdenum on sperm quality and testis oxidative stress

Xiao-Wei Zhai, Yu-Ling Zhang, Qiao Qi, Yu Bai, Xiao-Li Chen, Li-Jun Jin, Xue-Gang Ma, Runzhe Shu, Zi-Jun Yang, Feng-Jun Liu

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30 Citations (Scopus)


In order to investigate the effects of molybdenum (Mo) on sperm parameters and testicular oxidative stress, the ICR strain of adult mice were exposed to different doses of molybdenum for a sub-acute toxicity test. Compared to the control, our results showed that the sperm parameters, including the epididymis index, sperm motility, sperm count, and morphology, increased by a moderate dose of Mo (25 mg/L), but were negatively affected at high doses (>/= 100 mg/L). In addition, the changes of sperm parameters were accompanied with changes of the superoxide dismutase (SOD) activities, the glutathione peroxidase (GPx) activities, and the malondialdehyde (MDA) levels in testes. In conclusion, Mo affects the sperm quality through regulating the testicular oxidative stress in a complex manner.
Original languageEnglish
Pages (from-to)251 - 255
Number of pages5
JournalSystems Biology in Reproductive Medicine
Issue number5
Publication statusPublished - 2013

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