TY - JOUR
T1 - Effects of modulators of Ca 2+-activated, intermediate- conductance potassium channels on motility of the rat small intestine, in vivo
AU - Ferens, Dorota Maria
AU - Baell, Jonathan Bayldon
AU - Lessene, Guillaume
AU - Smith, Julia E
AU - Furness, John Barton
PY - 2007
Y1 - 2007
N2 - The movements of the intestine shift between different motor patterns, including between propulsion and mixing, but there is little information concerning mechanisms that may lead to changes in the patterns of motility. We have investigated the influence on intestinal motility of drugs that affect the after-hyperpolarization potential (AHP) of intrinsic primary afferent neurons (IPANs). The current of the AHP is carried by the intermediate conductance, calcium-activated, potassium (IK) channel. In anaesthetized rats, the IK channel blocker, 1-[(2-chlorophenyl)diphenylmethyl]-1H-pyrazole (0.05-1 mg kg -1, i.v.) disrupted the regular propulsive pressure waves that occur in the small intestine and reduced propulsion of the contents (after 1 mg kg -1, the fluid propelled was
AB - The movements of the intestine shift between different motor patterns, including between propulsion and mixing, but there is little information concerning mechanisms that may lead to changes in the patterns of motility. We have investigated the influence on intestinal motility of drugs that affect the after-hyperpolarization potential (AHP) of intrinsic primary afferent neurons (IPANs). The current of the AHP is carried by the intermediate conductance, calcium-activated, potassium (IK) channel. In anaesthetized rats, the IK channel blocker, 1-[(2-chlorophenyl)diphenylmethyl]-1H-pyrazole (0.05-1 mg kg -1, i.v.) disrupted the regular propulsive pressure waves that occur in the small intestine and reduced propulsion of the contents (after 1 mg kg -1, the fluid propelled was
UR - http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2982.2007.00898.x/pdf
U2 - 10.1111/j.1365-2982.2007.00898.x
DO - 10.1111/j.1365-2982.2007.00898.x
M3 - Article
SN - 1350-1925
VL - 19
SP - 383
EP - 389
JO - Neurogastroenterology & Motility
JF - Neurogastroenterology & Motility
IS - 5
ER -