Effects of gamma-tocopherol supplementation on thrombotic risk factors

Indu Singh, Alan H. Turner, Andrew J. Sinclair, Duo Li, John A. Hawley

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)


Objective: The antioxidant activity of vitamin E is derived primarily from alpha-tocopherol (α-T) and gamma-tocopherol (γ-T). Results of epidemiological studies have demonstrated an inverse relationship between vitamin E intake and coronary disease. However, the results of clinical trials using α-T are equivocal. We determined the effect of 5 weeks of 100 mg/d or 200 mg/d γ-T supplementation on thrombotic markers such as platelet reactivity, lipid profile and the inflammation marker C-reactive protein (CRP). Methods and results: Fourteen healthy subjects consumed 100 mg/day while 13 consumed 200 mg/d of γ-T and 12 received placebo (soybean capsules with less than 5 mg/d γ-T) in a double-blinded parallel study design. Fasting pre and post dose blood samples were analysed. Blood γ-T concentrations increased significantly (p<0.05) relative to dose during the intervention period. Both groups receiving active ingredients showed significantly lower platelet activation after supplementation (p<0.05). Subjects consuming 100 mg/d γ-T had significantly decreased LDL cholesterol, platelet aggregation and mean platelet volume (MPV) (p<0.05). Little effect of γ-T was observed on other parameters. Conclusions: These data suggest that γ-T supplementation may have a permissive role in decreasing the risk of thrombotic events by improving lipid profile and reducing platelet activity.

Original languageEnglish
Pages (from-to)422-428
Number of pages7
JournalAsia Pacific journal of clinical nutrition
Issue number3
Publication statusPublished - 1 Sep 2007
Externally publishedYes


  • CRP
  • Gamma tocopherol
  • Lipids
  • Platelets
  • Thrombotic risk factors

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