Effects of foetal growth restriction and preterm birth on cardiac morphology and function during infancy

Emily Cohen, Christie Whatley, Flora Y. Wong, Euan M. Wallace, Joanne C. Mockler, Alexsandria Odoi, Samantha Hollis, Rosemary S.C. Horne, Stephanie R. Yiallourou

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Aim: To investigate the effects of foetal growth restriction (FGR) and prematurity on cardiac morphology and function in infancy. We hypothesised that FGR and prematurity would both alter cardiac development. Methods: Cardiac morphology and function were evaluated in 24 preterm FGR infants (p-FGR) and 23 preterm and 19 term appropriately grown for gestational age infants (p-AGA and t-AGA, respectively) by conventional echocardiography and Tissue Doppler Imaging. p-FGR and p-AGA infants were studied on postnatal day 1 and all groups were studied at one-and six-months post-term age. Results: p-FGR infants demonstrated increased cardiac sphericity compared to AGA peers on postnatal day 1 (p = 0.004) and at one-month post-term age (p = 0.004). Posterior and relative wall thickness increased overtime in the p-FGR group only (p < 0.05). Systolic function was not different between groups. E/e’ ratio was higher in both preterm groups compared to the term group at one-month post-term age (p = 0.01). No statistically significant group differences were found at six-months post-term age. Conclusion: Foetal growth restriction was associated with subtle cardiac morphological changes, whereas both prematurity and FGR were associated with subclinical alterations in diastolic function.

Original languageEnglish
Pages (from-to)450-455
Number of pages6
JournalActa Paediatrica
Volume107
Issue number3
DOIs
Publication statusPublished - 1 Mar 2018

Keywords

  • Cardiology
  • Foetal growth restriction
  • Intrauterine growth restriction
  • Prematurity

Cite this

Cohen, Emily ; Whatley, Christie ; Wong, Flora Y. ; Wallace, Euan M. ; Mockler, Joanne C. ; Odoi, Alexsandria ; Hollis, Samantha ; Horne, Rosemary S.C. ; Yiallourou, Stephanie R. / Effects of foetal growth restriction and preterm birth on cardiac morphology and function during infancy. In: Acta Paediatrica. 2018 ; Vol. 107, No. 3. pp. 450-455.
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abstract = "Aim: To investigate the effects of foetal growth restriction (FGR) and prematurity on cardiac morphology and function in infancy. We hypothesised that FGR and prematurity would both alter cardiac development. Methods: Cardiac morphology and function were evaluated in 24 preterm FGR infants (p-FGR) and 23 preterm and 19 term appropriately grown for gestational age infants (p-AGA and t-AGA, respectively) by conventional echocardiography and Tissue Doppler Imaging. p-FGR and p-AGA infants were studied on postnatal day 1 and all groups were studied at one-and six-months post-term age. Results: p-FGR infants demonstrated increased cardiac sphericity compared to AGA peers on postnatal day 1 (p = 0.004) and at one-month post-term age (p = 0.004). Posterior and relative wall thickness increased overtime in the p-FGR group only (p < 0.05). Systolic function was not different between groups. E/e’ ratio was higher in both preterm groups compared to the term group at one-month post-term age (p = 0.01). No statistically significant group differences were found at six-months post-term age. Conclusion: Foetal growth restriction was associated with subtle cardiac morphological changes, whereas both prematurity and FGR were associated with subclinical alterations in diastolic function.",
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author = "Emily Cohen and Christie Whatley and Wong, {Flora Y.} and Wallace, {Euan M.} and Mockler, {Joanne C.} and Alexsandria Odoi and Samantha Hollis and Horne, {Rosemary S.C.} and Yiallourou, {Stephanie R.}",
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Effects of foetal growth restriction and preterm birth on cardiac morphology and function during infancy. / Cohen, Emily; Whatley, Christie; Wong, Flora Y.; Wallace, Euan M.; Mockler, Joanne C.; Odoi, Alexsandria; Hollis, Samantha; Horne, Rosemary S.C.; Yiallourou, Stephanie R.

In: Acta Paediatrica, Vol. 107, No. 3, 01.03.2018, p. 450-455.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Effects of foetal growth restriction and preterm birth on cardiac morphology and function during infancy

AU - Cohen, Emily

AU - Whatley, Christie

AU - Wong, Flora Y.

AU - Wallace, Euan M.

AU - Mockler, Joanne C.

AU - Odoi, Alexsandria

AU - Hollis, Samantha

AU - Horne, Rosemary S.C.

AU - Yiallourou, Stephanie R.

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N2 - Aim: To investigate the effects of foetal growth restriction (FGR) and prematurity on cardiac morphology and function in infancy. We hypothesised that FGR and prematurity would both alter cardiac development. Methods: Cardiac morphology and function were evaluated in 24 preterm FGR infants (p-FGR) and 23 preterm and 19 term appropriately grown for gestational age infants (p-AGA and t-AGA, respectively) by conventional echocardiography and Tissue Doppler Imaging. p-FGR and p-AGA infants were studied on postnatal day 1 and all groups were studied at one-and six-months post-term age. Results: p-FGR infants demonstrated increased cardiac sphericity compared to AGA peers on postnatal day 1 (p = 0.004) and at one-month post-term age (p = 0.004). Posterior and relative wall thickness increased overtime in the p-FGR group only (p < 0.05). Systolic function was not different between groups. E/e’ ratio was higher in both preterm groups compared to the term group at one-month post-term age (p = 0.01). No statistically significant group differences were found at six-months post-term age. Conclusion: Foetal growth restriction was associated with subtle cardiac morphological changes, whereas both prematurity and FGR were associated with subclinical alterations in diastolic function.

AB - Aim: To investigate the effects of foetal growth restriction (FGR) and prematurity on cardiac morphology and function in infancy. We hypothesised that FGR and prematurity would both alter cardiac development. Methods: Cardiac morphology and function were evaluated in 24 preterm FGR infants (p-FGR) and 23 preterm and 19 term appropriately grown for gestational age infants (p-AGA and t-AGA, respectively) by conventional echocardiography and Tissue Doppler Imaging. p-FGR and p-AGA infants were studied on postnatal day 1 and all groups were studied at one-and six-months post-term age. Results: p-FGR infants demonstrated increased cardiac sphericity compared to AGA peers on postnatal day 1 (p = 0.004) and at one-month post-term age (p = 0.004). Posterior and relative wall thickness increased overtime in the p-FGR group only (p < 0.05). Systolic function was not different between groups. E/e’ ratio was higher in both preterm groups compared to the term group at one-month post-term age (p = 0.01). No statistically significant group differences were found at six-months post-term age. Conclusion: Foetal growth restriction was associated with subtle cardiac morphological changes, whereas both prematurity and FGR were associated with subclinical alterations in diastolic function.

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