Effects of fenoldopam on renal blood flow and its function in a canine model of rhabdomyolysis

Clare Murray, F. Markos, H. M. Snow, T. Corcoran, N. Parfrey, G. D. Shorten

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Abstract

Background and objective: Our hypothesis was that fenoldopam, a selective DA1 agonist, would protect against rhabdomyolysis-induced renal injury. Methods: We studied the effects of intravenous fenoldopam (0.1-1.0 μg kg-1 min-1) or saline on renal blood flow and function in 10 anaesthetized Labrador dogs in whom rhabdomyolysis and myoglobinuric acute renal failure had been induced by administration of glycerol 50% (10 mL kg-1) intramuscularly. Haemodynamic measurements including renal blood flow and derived parameters of renal function including creatinine clearance were recorded before and for the 30 min following glycerol injection, and during the 3 h following commencement of each infusion. Serum malondialdehyde concentrations were measured before and 15 min after glycerol intramuscularly, and 30 and 150 min after commencement of the infusion. Results: In the fenoldopam group, creatinine clearance was less than placebo at 1 and 2 h after commencing the infusion (12.7 ± 11.5 versus 31.3 ± 9.9 mL min-1, P = 0.04; 8.5 ± 5.3 versus 20.1 ± 7.4 mL min-1, P = 0.03). A 140-fold increase in serum malondialdehyde concentration occurred in one dog (fenoldopam group). Conclusion: Fenoldopam increased the severity of the renal injury in this canine model of myoglobinuric acute renal failure.

Original languageEnglish
Pages (from-to)711-718
Number of pages8
JournalEuropean Journal of Anaesthesiology
Volume20
Issue number9
DOIs
Publication statusPublished - Sep 2003
Externally publishedYes

Keywords

  • Dopamine Agonists, fenoldopam
  • Kidney Diseases, acute, kidney failure
  • Muscular diseases, rhabdomyolysis

Cite this