Effects of drying methods on the release kinetics of Vitamin B12 in calcium alginate beads

Nada Abubakr, Xuqi Lin, Xiao Dong Chen

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21 Citations (Scopus)


The aim of this article was to investigate the morphology, swelling properties, and respective drug release kinetics of vitamin B12-loaded calcium alginate beads prepared by oven (air), vacuum, and freeze drying. The initial particle size was 1 mm. The mean bead sizes of dried Ca-alginate beads were 0.7, 0.8, and 0.9 mm for oven-, vacuum-, and freeze-dried beads, respectively. The surface morphology of the dried beads was affected by the different drying methods applied. Oven- and vacuum-dried beads shrank in size, and more cracks appeared on the surface of oven-dried beads. Freeze-dried beads almost retained the same size prior to drying; however, the surface was rougher and highly porous. The swelling profiles were also affected by the drying methods, whereby freeze-dried beads showed the fastest solvent uptake at the start of the experiment. The release data of the dried Ca-alginate beads were treated with first-order, Higuchi, Korsmeyer, and Peppas kinetic models. The data for oven and vacuum seemed to follow a combination of diffusion and swelling controlled release, whereas data from freeze-dried beads seemed to follow more diffusion-dominated controlled release.
Original languageEnglish
Pages (from-to)1258 - 1265
Number of pages8
JournalDrying Technology
Issue number11
Publication statusPublished - 2009

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