Effects of diffusion time on short-range hyperpolarized 3He diffusivity measurements in emphysema

David S Gierada, Jason C Woods, Andrew J Bierhals, Seth T Bartel, Jon H Ritter, Cliff Khuat Chye Choong, Nitin A Das, Cheng Hong, Thomas K Pilgram, Yulin V Chang, Richard E Jacob, James C Hogg, Richard J Battafarano, Joel D Cooper, Bryan F Meyers, G Alexander Patterson, Dmitriy A Yablonskiy, Mark S Conradi

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Abstract

PURPOSE: To characterize the effect of diffusion time on short-range hyperpolarized (3)He magnetic resonance imaging (MRI) diffusion measurements across a wide range of emphysema severity. MATERIALS AND METHODS: (3)He diffusion MRI was performed on 19 lungs or lobes resected from 18 subjects with varying degrees of emphysema using three diffusion times (1.6 msec, 5 msec, and 10 msec) at constant b value. Emphysema severity was quantified as the mean apparent diffusion coefficient (ADC) and as the percentage of pixels with ADC higher than multiple thresholds from 0.30-0.55 cm(2)/sec (ADC index).
Original languageEnglish
Pages (from-to)801 - 808
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Volume30
Issue number4
Publication statusPublished - 2009

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