Effects of diffusion time on short-range hyperpolarized 3He diffusivity measurements in emphysema

David S Gierada, Jason C Woods, Andrew J Bierhals, Seth T Bartel, Jon H Ritter, Cliff Khuat Chye Choong, Nitin A Das, Cheng Hong, Thomas K Pilgram, Yulin V Chang, Richard E Jacob, James C Hogg, Richard J Battafarano, Joel D Cooper, Bryan F Meyers, G Alexander Patterson, Dmitriy A Yablonskiy, Mark S Conradi

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Abstract

PURPOSE: To characterize the effect of diffusion time on short-range hyperpolarized (3)He magnetic resonance imaging (MRI) diffusion measurements across a wide range of emphysema severity. MATERIALS AND METHODS: (3)He diffusion MRI was performed on 19 lungs or lobes resected from 18 subjects with varying degrees of emphysema using three diffusion times (1.6 msec, 5 msec, and 10 msec) at constant b value. Emphysema severity was quantified as the mean apparent diffusion coefficient (ADC) and as the percentage of pixels with ADC higher than multiple thresholds from 0.30-0.55 cm(2)/sec (ADC index).
Original languageEnglish
Pages (from-to)801 - 808
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Volume30
Issue number4
Publication statusPublished - 2009

Cite this

Gierada, D. S., Woods, J. C., Bierhals, A. J., Bartel, S. T., Ritter, J. H., Choong, C. K. C., Das, N. A., Hong, C., Pilgram, T. K., Chang, Y. V., Jacob, R. E., Hogg, J. C., Battafarano, R. J., Cooper, J. D., Meyers, B. F., Patterson, G. A., Yablonskiy, D. A., & Conradi, M. S. (2009). Effects of diffusion time on short-range hyperpolarized 3He diffusivity measurements in emphysema. Journal of Magnetic Resonance Imaging, 30(4), 801 - 808.