Effects of conjugated linolenic acid and conjugated linoleic acid on lipid metabolism in mice

Gaofeng Yuan, Haiyan Sun, Andrew J. Sinclair, Duo Li

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34 Citations (Scopus)

Abstract

The effects of two isomers of conjugated linolenic acid (CLnA), α-eleostearic acid (α-ESA) and punicic acid (PA), on body fat and lipid metabolism were investigated, compared with a conjugated linoleic acid (CLA) mixture (primarily cis9,trans11- and trans10,cis12-18:2) and α-linolenic acid (ALA), a non-con-jugated octadecatrienoic acid, in the present study. ICR mice were fed either a control diet or one of four experimental diets supplemented with 1% α-ESA, 1% PA, 1% CLA mixture and 1% ALA in the form of triacylglycerols (TAG) for 6 weeks. The weights of perirenal and epididymal adipose tissues were signifi-cantly decreased while the liver weight was significantly increased in mice fed CLA, compared with the control. In contrast to CLA, the tissue weights in α-ESA-, PA- and ALA-fed mice were not affected. No significant differences were observed in TAG, total cholesterol, high-density lipoprotein and low-density lipoprotein cholesterol levels among the five groups. The liver TAG level was significantly decreased in mice fed α-ESA and PA while it was significantly increased in mice fed the CLA mixture. These results indicate that CLnA and CLA have differential effects on body fat mass and liver TAG levels in mice.

Original languageEnglish
Pages (from-to)537-545
Number of pages9
JournalEuropean Journal of Lipid Science and Technology
Volume111
Issue number6
DOIs
Publication statusPublished - 1 Jun 2009
Externally publishedYes

Keywords

  • α-Eleostearic acid
  • α-Linolenic acid
  • Adipose tissue
  • Liver lipids
  • Punicic acid

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