Effects of Colistin on the Sensory Nerve Conduction Velocity and F-wave in Mice

Chongshan Dai, Shusheng Tang, Jichang Li, Jiping Wang, Xilong Xiao

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Abstract

The aim of this study was to examine the changes of sensory nerve conduction velocity (SNCV) and F-wave for colistin-induced peripheral neurotoxicity using a mouse model. Mice were administered with colistin 5, 7.5 and 15 mg/kg/day via a 3-min. intravenous infusion. The sensory nerve conduction velocity (SNCV) and F-wave were measured using the bipolar recording electrodes. The SNCV and F-wave latency changed in a dose- and time-dependent manner. The significant increase of F-wave latency and significant decrease of SNCV appeared on day 3 (p < 0.05 and 0.01, respectively) in the 15 mg/kg/day group, and they were markedly changed on day 7 in the 7.5 mg/kg/day (p < 0.01 and 0.05, respectively) and 15 mg/kg/day groups (both p < 0.01). In addition, F-wave latency also significantly increased on day 7 in the 5 mg/kg/day group (p < 0.05) without any clinical signs. These results indicate that SNCV and F-wave latency were more sensitive in colistin-induced neurotoxicity in mice, which highlights the early monitoring tool of polymyxins neurotoxicity in the clinic.

Original languageEnglish
Pages (from-to)577-580
Number of pages4
JournalBasic & Clinical Pharmacology & Toxicology
Volume115
Issue number6
DOIs
Publication statusPublished - 2014

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