Effects of caffeine on renal and pulmonary function in preterm newborn lambs

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Abstract

Introduction:Caffeine administration is associated with a reduction in bronchopulmonary dysplasia, assisted ventilation, patent ductus arteriosus (DA) and cerebral palsy in preterm infants, but the mechanisms are unknown. Our aim was to determine the effects of acute caffeine administration on renal and pulmonary function in preterm lambs.Methods:Lambs were delivered by caesarean section at 126 days of gestation and ventilated with a tidal volume of 5 ml/kg, 60 breaths/min and 5 cmH(2)O positive end-expiratory pressure. After 30 minutes, lambs received 40 mg/kg caffeine i.v (n=7) or saline (controls; n=6) over 30 minutes and were ventilated for 2 hours.Results:Arterial caffeine concentrations reached 35.9 +/- 7.8 mg/l. Urine output was significantly higher after caffeine treatment than in controls (5.86 +/- 1.95 vs 0.76 +/- 0.94 ml/kg, area under curve p=0.041). Mean heart rate was significantly higher after caffeine treatment than in controls (211 +/- 8 vs 169 +/- 15 beats per minute, p
Original languageEnglish
Pages (from-to)19 - 25
Number of pages7
JournalPediatric Research
Volume72
Issue number1
DOIs
Publication statusPublished - 2012

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