Effects of caffeine on renal and pulmonary function in preterm newborn lambs

Kelly Jane Crossley; Beth Joyce Allison; Graeme Polglase; Colin J Morley; Richard Harding; Peter G Davis; Timothy James Murugesan Moss; Stuart Brian Hooper

doi:10.1038/pr.2012.49

Effects of caffeine on renal and pulmonary function in preterm newborn lambs

Kelly Jane Crossley, Beth Joyce Allison, Graeme Polglase, Colin J Morley, Richard Harding, Peter G Davis, Timothy James Murugesan Moss, Stuart Brian Hooper

Research output: Contribution to journal › Article › Research › peer-review

16 Citations (Scopus)

Abstract

Introduction:Caffeine administration is associated with a reduction in bronchopulmonary dysplasia, assisted ventilation, patent ductus arteriosus (DA) and cerebral palsy in preterm infants, but the mechanisms are unknown. Our aim was to determine the effects of acute caffeine administration on renal and pulmonary function in preterm lambs.Methods:Lambs were delivered by caesarean section at 126 days of gestation and ventilated with a tidal volume of 5 ml/kg, 60 breaths/min and 5 cmH(2)O positive end-expiratory pressure. After 30 minutes, lambs received 40 mg/kg caffeine i.v (n=7) or saline (controls; n=6) over 30 minutes and were ventilated for 2 hours.Results:Arterial caffeine concentrations reached 35.9 +/- 7.8 mg/l. Urine output was significantly higher after caffeine treatment than in controls (5.86 +/- 1.95 vs 0.76 +/- 0.94 ml/kg, area under curve p=0.041). Mean heart rate was significantly higher after caffeine treatment than in controls (211 +/- 8 vs 169 +/- 15 beats per minute, p

Original language	English
Pages (from-to)	19 - 25
Number of pages	7
Journal	Pediatric Research
Volume	72
Issue number	1
DOIs	https://doi.org/10.1038/pr.2012.49
Publication status	Published - 2012

Access to Document

10.1038/pr.2012.49

Cite this

@article{3e7100bc96c64d459938fddd866d476e,

title = "Effects of caffeine on renal and pulmonary function in preterm newborn lambs",

abstract = "Introduction:Caffeine administration is associated with a reduction in bronchopulmonary dysplasia, assisted ventilation, patent ductus arteriosus (DA) and cerebral palsy in preterm infants, but the mechanisms are unknown. Our aim was to determine the effects of acute caffeine administration on renal and pulmonary function in preterm lambs.Methods:Lambs were delivered by caesarean section at 126 days of gestation and ventilated with a tidal volume of 5 ml/kg, 60 breaths/min and 5 cmH(2)O positive end-expiratory pressure. After 30 minutes, lambs received 40 mg/kg caffeine i.v (n=7) or saline (controls; n=6) over 30 minutes and were ventilated for 2 hours.Results:Arterial caffeine concentrations reached 35.9 +/- 7.8 mg/l. Urine output was significantly higher after caffeine treatment than in controls (5.86 +/- 1.95 vs 0.76 +/- 0.94 ml/kg, area under curve p=0.041). Mean heart rate was significantly higher after caffeine treatment than in controls (211 +/- 8 vs 169 +/- 15 beats per minute, p",

author = "Crossley, {Kelly Jane} and Allison, {Beth Joyce} and Graeme Polglase and Morley, {Colin J} and Richard Harding and Davis, {Peter G} and Moss, {Timothy James Murugesan} and Hooper, {Stuart Brian}",

year = "2012",

doi = "10.1038/pr.2012.49",

language = "English",

volume = "72",

pages = "19 -- 25",

journal = "Pediatric Research",

issn = "0031-3998",

publisher = "Nature Publishing Group",

number = "1",

}

TY - JOUR

T1 - Effects of caffeine on renal and pulmonary function in preterm newborn lambs

AU - Crossley, Kelly Jane

AU - Allison, Beth Joyce

AU - Polglase, Graeme

AU - Morley, Colin J

AU - Harding, Richard

AU - Davis, Peter G

AU - Moss, Timothy James Murugesan

AU - Hooper, Stuart Brian

PY - 2012

Y1 - 2012

N2 - Introduction:Caffeine administration is associated with a reduction in bronchopulmonary dysplasia, assisted ventilation, patent ductus arteriosus (DA) and cerebral palsy in preterm infants, but the mechanisms are unknown. Our aim was to determine the effects of acute caffeine administration on renal and pulmonary function in preterm lambs.Methods:Lambs were delivered by caesarean section at 126 days of gestation and ventilated with a tidal volume of 5 ml/kg, 60 breaths/min and 5 cmH(2)O positive end-expiratory pressure. After 30 minutes, lambs received 40 mg/kg caffeine i.v (n=7) or saline (controls; n=6) over 30 minutes and were ventilated for 2 hours.Results:Arterial caffeine concentrations reached 35.9 +/- 7.8 mg/l. Urine output was significantly higher after caffeine treatment than in controls (5.86 +/- 1.95 vs 0.76 +/- 0.94 ml/kg, area under curve p=0.041). Mean heart rate was significantly higher after caffeine treatment than in controls (211 +/- 8 vs 169 +/- 15 beats per minute, p

AB - Introduction:Caffeine administration is associated with a reduction in bronchopulmonary dysplasia, assisted ventilation, patent ductus arteriosus (DA) and cerebral palsy in preterm infants, but the mechanisms are unknown. Our aim was to determine the effects of acute caffeine administration on renal and pulmonary function in preterm lambs.Methods:Lambs were delivered by caesarean section at 126 days of gestation and ventilated with a tidal volume of 5 ml/kg, 60 breaths/min and 5 cmH(2)O positive end-expiratory pressure. After 30 minutes, lambs received 40 mg/kg caffeine i.v (n=7) or saline (controls; n=6) over 30 minutes and were ventilated for 2 hours.Results:Arterial caffeine concentrations reached 35.9 +/- 7.8 mg/l. Urine output was significantly higher after caffeine treatment than in controls (5.86 +/- 1.95 vs 0.76 +/- 0.94 ml/kg, area under curve p=0.041). Mean heart rate was significantly higher after caffeine treatment than in controls (211 +/- 8 vs 169 +/- 15 beats per minute, p

UR - http://www.nature.com/pr/journal/v72/n1/pdf/pr201249a.pdf

U2 - 10.1038/pr.2012.49

DO - 10.1038/pr.2012.49

M3 - Article

SN - 0031-3998

VL - 72

SP - 19

EP - 25

JO - Pediatric Research

JF - Pediatric Research

IS - 1

ER -

Effects of caffeine on renal and pulmonary function in preterm newborn lambs

Abstract

Access to Document

Other files and links

Cite this