Effects of beta-band and gamma-band rhythmic stimulation on motor inhibition

Inge Leunissen; Manon Van Steenkiste; Kirstin-Friederike Heise; Thiago Santos Monteiro; Kyle Dunovan; Dante Mantini; James Coxon; Stephan Swinnen

doi:10.1016/j.isci.2022.104338

Effects of beta-band and gamma-band rhythmic stimulation on motor inhibition

Inge Leunissen, Manon Van Steenkiste, Kirstin-Friederike Heise, Thiago Santos Monteiro, Kyle Dunovan, Dante Mantini, James Coxon, Stephan Swinnen

Psychology

Research output: Contribution to journal › Article › Research › peer-review

10 Citations (Scopus)

Abstract

To investigate whether beta oscillations are causally related to motor inhibition, thirty-six participants underwent two concurrent transcranial alternating current stimulation (tACS) and electroencephalography (EEG) sessions during which either beta (20 Hz) or gamma (70 Hz) stimulation was applied while participants performed a stop-signal task. In addition, we acquired magnetic resonance images to simulate the electric field during tACS. 20 Hz stimulation targeted at the pre-supplementary motor area enhanced inhibition and increased beta oscillatory power around the time of the stop-signal in trials directly following stimulation. The increase in inhibition on stop trials followed a dose-response relationship with the strength of the individually simulated electric field. Computational modeling revealed that 20 and 70 Hz stimulation had opposite effects on the braking process. These results highlight that the effects of tACS are state-dependent and demonstrate that fronto-central beta activity is causally related to successful motor inhibition, supporting its use as a functional biomarker.

Original language	English
Article number	104338
Number of pages	19
Journal	iScience
Volume	25
Issue number	5
DOIs	https://doi.org/10.1016/j.isci.2022.104338
Publication status	Published - 20 May 2022

Keywords

Behavioral neuroscience
Biological sciences
Neuroscience
Sensory neuroscience

Access to Document

10.1016/j.isci.2022.104338Licence: CC BY-NC-ND

Cite this

@article{5ac2bd22877440bba8fe0a8938bccb31,

title = "Effects of beta-band and gamma-band rhythmic stimulation on motor inhibition",

abstract = "To investigate whether beta oscillations are causally related to motor inhibition, thirty-six participants underwent two concurrent transcranial alternating current stimulation (tACS) and electroencephalography (EEG) sessions during which either beta (20 Hz) or gamma (70 Hz) stimulation was applied while participants performed a stop-signal task. In addition, we acquired magnetic resonance images to simulate the electric field during tACS. 20 Hz stimulation targeted at the pre-supplementary motor area enhanced inhibition and increased beta oscillatory power around the time of the stop-signal in trials directly following stimulation. The increase in inhibition on stop trials followed a dose-response relationship with the strength of the individually simulated electric field. Computational modeling revealed that 20 and 70 Hz stimulation had opposite effects on the braking process. These results highlight that the effects of tACS are state-dependent and demonstrate that fronto-central beta activity is causally related to successful motor inhibition, supporting its use as a functional biomarker.",

keywords = "Behavioral neuroscience, Biological sciences, Neuroscience, Sensory neuroscience",

author = "Inge Leunissen and {Van Steenkiste}, Manon and Kirstin-Friederike Heise and {Santos Monteiro}, Thiago and Kyle Dunovan and Dante Mantini and James Coxon and Stephan Swinnen",

note = "Funding Information: This work was supported by the Internal Research Fund KU Leuven (C16/15/070), Research Foundation Flanders (FWO) grants ( G089818N , G0F7616N , G093616N , and I005018N ) and an Excellence of Science grant ( EOS 30446199 , MEMODYN), awarded to S.P.S.., D.M., and coworkers. I.L. is supported by an individual fellowship of the FWO ( 12M6718N ) and EU ( Marie Sk{\l}odowska-Curie Actions [MSCA] 798619 ). J.C. is supported by the Australian Research Council (ARC DP200100234 and DP180102066 ) and the Office of Naval Research Global ( N62909-18-1-2174 ). Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

month = may,

day = "20",

doi = "10.1016/j.isci.2022.104338",

language = "English",

volume = "25",

journal = "iScience",

issn = "2589-0042",

publisher = "Elsevier",

number = "5",

}

TY - JOUR

T1 - Effects of beta-band and gamma-band rhythmic stimulation on motor inhibition

AU - Leunissen, Inge

AU - Van Steenkiste, Manon

AU - Heise, Kirstin-Friederike

AU - Santos Monteiro, Thiago

AU - Dunovan, Kyle

AU - Mantini, Dante

AU - Coxon, James

AU - Swinnen, Stephan

N1 - Funding Information: This work was supported by the Internal Research Fund KU Leuven (C16/15/070), Research Foundation Flanders (FWO) grants ( G089818N , G0F7616N , G093616N , and I005018N ) and an Excellence of Science grant ( EOS 30446199 , MEMODYN), awarded to S.P.S.., D.M., and coworkers. I.L. is supported by an individual fellowship of the FWO ( 12M6718N ) and EU ( Marie Skłodowska-Curie Actions [MSCA] 798619 ). J.C. is supported by the Australian Research Council (ARC DP200100234 and DP180102066 ) and the Office of Naval Research Global ( N62909-18-1-2174 ). Publisher Copyright: © 2022 The Authors

PY - 2022/5/20

Y1 - 2022/5/20

N2 - To investigate whether beta oscillations are causally related to motor inhibition, thirty-six participants underwent two concurrent transcranial alternating current stimulation (tACS) and electroencephalography (EEG) sessions during which either beta (20 Hz) or gamma (70 Hz) stimulation was applied while participants performed a stop-signal task. In addition, we acquired magnetic resonance images to simulate the electric field during tACS. 20 Hz stimulation targeted at the pre-supplementary motor area enhanced inhibition and increased beta oscillatory power around the time of the stop-signal in trials directly following stimulation. The increase in inhibition on stop trials followed a dose-response relationship with the strength of the individually simulated electric field. Computational modeling revealed that 20 and 70 Hz stimulation had opposite effects on the braking process. These results highlight that the effects of tACS are state-dependent and demonstrate that fronto-central beta activity is causally related to successful motor inhibition, supporting its use as a functional biomarker.

AB - To investigate whether beta oscillations are causally related to motor inhibition, thirty-six participants underwent two concurrent transcranial alternating current stimulation (tACS) and electroencephalography (EEG) sessions during which either beta (20 Hz) or gamma (70 Hz) stimulation was applied while participants performed a stop-signal task. In addition, we acquired magnetic resonance images to simulate the electric field during tACS. 20 Hz stimulation targeted at the pre-supplementary motor area enhanced inhibition and increased beta oscillatory power around the time of the stop-signal in trials directly following stimulation. The increase in inhibition on stop trials followed a dose-response relationship with the strength of the individually simulated electric field. Computational modeling revealed that 20 and 70 Hz stimulation had opposite effects on the braking process. These results highlight that the effects of tACS are state-dependent and demonstrate that fronto-central beta activity is causally related to successful motor inhibition, supporting its use as a functional biomarker.

KW - Behavioral neuroscience

KW - Biological sciences

KW - Neuroscience

KW - Sensory neuroscience

UR - http://www.scopus.com/inward/record.url?scp=85130381410&partnerID=8YFLogxK

U2 - 10.1016/j.isci.2022.104338

DO - 10.1016/j.isci.2022.104338

M3 - Article

AN - SCOPUS:85130381410

SN - 2589-0042

VL - 25

JO - iScience

JF - iScience

IS - 5

M1 - 104338

ER -

Effects of beta-band and gamma-band rhythmic stimulation on motor inhibition

Abstract

Keywords

Access to Document

Other files and links

How exercise modulates neural plasticity and memory consolidation

The influence of attentional selection on perceptual decision making

Cite this

Effects of beta-band and gamma-band rhythmic stimulation on motor inhibition

Abstract

Keywords

Access to Document

Other files and links

Projects

How exercise modulates neural plasticity and memory consolidation

The influence of attentional selection on perceptual decision making

Cite this